The Significance of Exosomes in Pathogenesis, Diagnosis, and Treatment of Esophageal Cancer

被引：29
作者：
Jing, Zhao [1 ]
Chen, Kai [2 ]
Gong, Ling [3 ]
机构：
[1] Zhejiang Hosp, Dept Oncol, Hangzhou, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Dept Cardiovasc & Thorac Surg, Yuying Childrens Hosp, Affiliated Hosp 2, Wenzhou, Zhejiang, Peoples R China
[3] Hangzhou Normal Univ, Dept Infect Dis Liver Dis, Affiliated Hosp, Zhejiang, Peoples R China
来源：
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2021年 / 16卷
关键词：
exosome; esophageal cancer; biomarkers; liquid biopsy; prognosis; SQUAMOUS-CELL CARCINOMA; TUMOR MICROENVIRONMENT; MESENCHYMAL TRANSITION; POOR-PROGNOSIS; UP-REGULATION; T-CELLS; SERUM; METASTASIS; PROMOTES; PROLIFERATION;
D O I：
10.2147/IJN.S321555
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Esophageal cancer is one of the most common malignancy in China with high mortality. Understanding pathogenesis and identifying early diagnosis biomarkers can significantly improve the prognosis of patients with esophageal cancer. Exosomes are small vesicular structures containing a variety of components (including DNA, RNA, and proteins) mediating cell-to-cell material exchange and signal communication. Growing evidences have shown that exosomes and its components are involved in growth, metastasis and angiogenesis in cancer, and could also be used as diagnostic and prognostic markers. In this review, we summarized recent progress to elucidate the significance of exosomes in the esophageal cancer progression, microenvironment remodeling, therapeutic resistance, and immunosuppression. We also discuss the utility of exosomes as diagnostic and prognostic biomarkers and therapeutic tool in esophageal cancer.
引用
收藏
页码：6115 / 6127
页数：13
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