Disorders of consciousness: Moving from passive to resting state and active paradigms

被引：16

作者：

Bruno, M. A. ^{[2
]}

Soddu, A. ^{[2
]}

Demertzi, A. ^{[2
]}

Laureys, S. ^{[1
,2
]}

Gosseries, O. ^{[2
]}

Schnakers, C. ^{[2
]}

Boly, M. ^{[2
]}

Noirhomme, Q. ^{[2
]}

Thonnard, M. ^{[2
]}

Chatelle, C. ^{[2
]}

Vanhaudenhuyse, A. ^{[2
]}

机构：

[1] Univ Liege, Cyclotron Res Ctr, Coma Sci Grp, Liege, Belgium

[2] Univ Hosp Liege, Liege, Belgium

来源：

COGNITIVE NEUROSCIENCE | 2010年 / 1卷 / 03期

关键词：

Consciousness; Vegetative state; Resting state; fMRI; Active paradigms; LOCKED-IN SYNDROME; REGIONAL CEREBRAL METABOLISM; EVENT-RELATED POTENTIALS; VEGETATIVE STATE; BRAIN ACTIVITY; DEFAULT-MODE; OWN NAME; FUNCTIONAL CONNECTIVITY; GLUCOSE-UTILIZATION; COGNITIVE FUNCTION;

D O I：

10.1080/17588928.2010.485677

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Following coma, some patients will recover wakefulness without signs of consciousness (i.e., vegetative state) or may show nonreflexive movements but with no ability for functional communication (i.e., minimally conscious state). Currently, there remains a high rate of misdiagnosis of the vegetative state. The increasing use of fMRI and EEG tools permits the clinical characterization of these patients to be improved. We first discuss "resting metabolism" and "passive activation" paradigms, used in neuroimaging and evoked potential studies, which merely identify neural activation reflecting "automatic" processing-that is, occurring without the patient's willful intervention. Secondly, we present an alternative approach consisting of instructing subjects to imagine well-defined sensory-motor or cognitive-mental actions. This strategy reflects volitional neural activation and, hence, witnesses awareness. Finally, we present results on blood-oxgen-level-dependent "default mode network"/resting state studies that might be a promising tool in the diagnosis of these challenging patients.

引用

页码：193 / 203

页数：11

共 64 条

[31] Impaired effective cortical connectivity in vegetative state: Preliminary investigation using PET [J].