Systemic anaphylaxis is prevented in alloxan-diabetic rats by a mechanism dependent on glucocorticoids

被引：21

作者：

Carvalho, VF ^{[1
]}

Barreto, EO ^{[1
]}

Diaz, BL ^{[1
]}

Serra, MF ^{[1
]}

Azevedo, V ^{[1
]}

Cordeiro, RSB ^{[1
]}

Martins, MA ^{[1
]}

Silva, PMRE ^{[1
]}

机构：

[1] Fiocruz MS, Lab Inflamacao, Dept Fisiol & Farmacodinam, Inst Oswaldo Cruz, BR-21045900 Rio De Janeiro, Brazil

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2003年 / 472卷 / 03期

关键词：

diabetes; systemic anaphylaxis; glucocorticoid; mast cell;

D O I：

10.1016/S0014-2999(03)01934-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study was undertaken to examine whether glucocorticoids could be implicated in the hyporesponsiveness of diabetic rats to systemic anaphylaxis. Rats were actively sensitized with a mixture of Al(OH)(3) plus ovalbumin and challenged i.v. with ovalbumin 14 days later. Diabetes was induced by alloxan-injected i.v. either before or after sensitization. Elevation of total and specific serum immunoglobulin E (IgE) was abolished in rats turned diabetic and then sensitised, but not in those first sensitised and then turned diabetic. In both conditions, increased serum corticosterone levels occurred in parallel with protection of diabetic animals against fatal shock, intestinal haemorrhage and elevation in plasma histamine levels evoked by antigen challenge. The resistance of diabetic rats to fatal shock was no longer significantly different from that of non-diabetic rats following treatment with the glucocorticoid receptor antagonist RU 486 (mifepristone). These findings indicate that endogenous glucocorticoid plays a pivotal role in the phenomenon of hyporeactivity to systemic anaphylaxis in alloxan-diabetic rats. (C) 2003 Elsevier B.V All rights reserved.

引用

页码：221 / 227

页数：7

共 25 条

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