Furanocoumarins-imperatorin inhibits myocardial hypertrophy both in vitro and in vivo

被引：49
|
作者：
Zhang, Yan [1 ]
Cao, YanJun [1 ]
Zhan, YingZhuan [1 ]
Duan, HaiJie [1 ]
He, LangChong [1 ]
机构：
[1] Xi An Jiao Tong Univ, Sch Med, Xian 710049, Peoples R China
来源：
FITOTERAPIA | 2010年 / 81卷 / 08期
基金：
中国国家自然科学基金;
关键词：
Imperatorin; Myocardial hypertrophy; Myocyte hypertrophy; Anti-cardiac hypertrophy agent; CELL-MEMBRANE CHROMATOGRAPHY; ATRACTYLODES-MACROCEPHALA KOIDZ; LEFT-VENTRICULAR HYPERTROPHY; INDUCED CARDIAC-HYPERTROPHY; RADIOLIGAND-BINDING ASSAY; CORONARY-HEART-DISEASE; ANGIOTENSIN-II; ATRACTYLENOLIDE-I; NATURAL-PRODUCTS; SILICA SURFACE;
D O I：
10.1016/j.fitote.2010.07.023
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The furanocoumarin imperatorin has been reported to have hypotensive effect, and we have investigated its activity on myocardial hypertrophy. Imperatorin displayed similar chromatographic retention peak to verapamil in the model of cardiac muscle/cell membrane chromatography, and could reduce in a concentration-dependent way protein content and cell size of myocytes prestimulated with angiotensin II. The ratio of heart weight to body weight (mg/g) (4.13 +/- 0.06 in SHRs, 3.77 +/- 0.02 with imperatorin 25 mg kg(-1) d(-1) 16 17 ig, P<0.01) was significantly lower in the imperatorin-treated SHRs. Taken together, our observations show that imperatorin exerts anti-hypertrophic effect both in vitro and in vivo. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：1188 / 1195
页数：8
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