Furanocoumarins-imperatorin inhibits myocardial hypertrophy both in vitro and in vivo

被引：49

作者：

Zhang, Yan ^{[1
]}

Cao, YanJun ^{[1
]}

Zhan, YingZhuan ^{[1
]}

Duan, HaiJie ^{[1
]}

He, LangChong ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Sch Med, Xian 710049, Peoples R China

来源：

FITOTERAPIA | 2010年 / 81卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Imperatorin; Myocardial hypertrophy; Myocyte hypertrophy; Anti-cardiac hypertrophy agent; CELL-MEMBRANE CHROMATOGRAPHY; ATRACTYLODES-MACROCEPHALA KOIDZ; LEFT-VENTRICULAR HYPERTROPHY; INDUCED CARDIAC-HYPERTROPHY; RADIOLIGAND-BINDING ASSAY; CORONARY-HEART-DISEASE; ANGIOTENSIN-II; ATRACTYLENOLIDE-I; NATURAL-PRODUCTS; SILICA SURFACE;

D O I：

10.1016/j.fitote.2010.07.023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The furanocoumarin imperatorin has been reported to have hypotensive effect, and we have investigated its activity on myocardial hypertrophy. Imperatorin displayed similar chromatographic retention peak to verapamil in the model of cardiac muscle/cell membrane chromatography, and could reduce in a concentration-dependent way protein content and cell size of myocytes prestimulated with angiotensin II. The ratio of heart weight to body weight (mg/g) (4.13 +/- 0.06 in SHRs, 3.77 +/- 0.02 with imperatorin 25 mg kg(-1) d(-1) 16 17 ig, P<0.01) was significantly lower in the imperatorin-treated SHRs. Taken together, our observations show that imperatorin exerts anti-hypertrophic effect both in vitro and in vivo. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：1188 / 1195

页数：8

共 50 条

[31] Depletion of STYK1 inhibits intrahepatic cholangiocarcinoma development both in vitro and in vivo
Chen, Mei-yuan
Zhang, Hao
Jiang, Jian-xin
Sun, Cheng-yi
Yu, Chao
Tian, She
TUMOR BIOLOGY, 2016, 37 (10) : 14173 - 14181
[32] A novel non-containing-nitrogen bisphosphonate inhibits both in vitro and in vivo angiogenesis
Hamma-Kourbali, Y
Di Benedetto, M
Ledoux, D
Oudar, O
Leroux, Y
Lecouvey, M
Kraemer, M
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 310 (03) : 816 - 823
[33] Intestinal inflammation inhibits the expression of a marker for colonocyte differentiation both in vitro and in vivo.
Wu, GD
Yang, HY
Katz, JP
Silberg, DG
Furth, EE
GASTROENTEROLOGY, 1996, 110 (04) : A1047 - A1047
[34] Miltefosine Inhibits Human Mast Cell Activation and Mediator Release Both In Vitro and In Vivo
Weller, Karsten
Artuc, Metin
Jennings, Gary
Friedrichson, Tim
Guhl, Sven
dos Santos, Rosaly V.
Suender, Cathleen
Zuberbier, Torsten
Maurer, Marcus
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2009, 129 (02) : 496 - 498
[35] The sphingosine-1-phosphate derivative NHOBTD inhibits angiogenesis both in vitro and in vivo
Kim, Beom Seok
Park, Hyomi
Ko, Seung Hwan
Lee, Won Koo
Kwon, Ho Jeong
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 413 (02) : 189 - 193
[36] MicroRNA-34a Inhibits the Proliferation and Metastasis of Osteosarcoma Cells Both In Vitro and In Vivo
Yan, Kang
Gao, Jie
Yang, Tongtao
Ma, Qiong
Qiu, Xiuchun
Fan, Qingyu
Ma, Baoan
PLOS ONE, 2012, 7 (03):
[37] Candesartan inhibits Toll-like receptor expression and activity both in vitro and in vivo
Dasu, Mohan R.
Riosvelasco, Andrea C.
Jialal, Ishwarlal
ATHEROSCLEROSIS, 2009, 202 (01) : 76 - 83
[38] Bigelovin inhibits colorectal cancer by suppressing the growth and inducing apoptosis both in vitro and in vivo
Li, Ming-Yue
Yue, Grace Gar-Lee
Tsui, Stephen Kwok-Wing
Fung, Kwok-Pui
Tan, Ning-Hua
Lau, Clara Bik-San
CANCER RESEARCH, 2016, 76
[39] IN VITRO AND IN VIVO INHIBITION OF CYP1A2 METABOLISM BY NATURAL FURANOCOUMARINS
Li, H.
Zhuang, X.
Kong, L.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2014, 115 : 164 - 164
[40] Quercetin Prevents In Vivo and In Vitro Myocardial Hypertrophy Through the Proteasome-GSK-3 Pathway
Chen, Kuixiang
Rekep, Mubarak
Wei, Wei
Wu, Qian
Xue, Qin
Li, Sujuan
Tian, Jiahui
Yi, Quan
Zhang, Genshui
Zhang, Guiping
Xiao, Qing
Luo, Jiandong
Liu, Yinghua
CARDIOVASCULAR DRUGS AND THERAPY, 2018, 32 (01) : 5 - 21

← 1 2 3 4 5 →