Potential Therapeutic Relevance of CRISPR/Cas9 Guided Epigenetic Reg-ulations for Neuropsychiatric Disorders

被引：12
作者：
Singh, Desh D. [1 ]
Verma, Ravi [2 ]
Parimoo, Piyush [1 ,3 ,4 ]
Sahu, Ashish [1 ]
Kumar, Vikram [1 ]
Upadhyay, Era [1 ]
Yadav, Dharmendra K. [5 ]
机构：
[1] Amity Univ Rajasthan, Amity Inst Biotechnol, Jaipur, Rajasthan, India
[2] Pohang Univ Sci & Technol POSTECH, Div Integrat Biosci & Biotechnol, Pohang 37673, South Korea
[3] Panjab Univ, Ctr Phenomenol & Cognit Sci, Chandigarh, India
[4] Chandigarh Univ, Univ Inst Neural & Cognit Sci, Chandigarh, Punjab, India
[5] Gachon Univ Med & Sci, Coll Pharm, Hambakmoeiro 191, Incheon, South Korea
来源：
CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2021年 / 21卷 / 10期
基金：
新加坡国家研究基金会;
关键词：
Neuropsychiatric Disorders; Epigenetic regulations; Transcription factor; CRISPR; Cas9; Gene editing; Neuronal development; Therapeutic applications; GENE-EXPRESSION; DNA METHYLATION; STRAIN DIFFERENTIATION; NEUROTROPHIC FACTOR; GENOME; IDENTIFICATION; SCHIZOPHRENIA; CRISPR-CAS9; MECHANISMS; BRAIN;
D O I：
10.2174/1568026621666210317154502
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Brain function activity is regulated by several mechanisms of genetic and epigenetic factors such as histone modelling, DNA methylation, and non-coding RNA. Alterations in these regulatory mechanisms affect the normal development of neurons that causes Neuropsychiatric Disorders (ND). However, it is required to analyse the functional significance of neuropsychiatric disorders associated with a molecular mechanism to bring about therapeutic advances in early diagnosis and treatment of the patients. The CRISPR/Cas 9 (Clustered Regularly Interspaced Short Palindromic Repeats) genome editing tools have revolutionized multiple genome and epigenome manipulation targets the same time. This review discussed the possibilities of using CRISPR/Cas 9 tools during molecular mechanism in the ND as a therapeutic approach to overcome ND that is caused due to genetic and epigenetic abnormalities.
引用
收藏
页码：878 / 894
页数：17
相关论文
共 153 条
  • [1] RNA interference: Biology, mechanism, and applications
    Agrawal, N
    Dasaradhi, PVN
    Mohmmed, A
    Malhotra, P
    Bhatnagar, RK
    Mukherjee, SK
    [J]. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2003, 67 (04) : 657 - +
  • [2] KINESIN FAMILY IN MURINE CENTRAL-NERVOUS-SYSTEM
    AIZAWA, H
    SEKINE, Y
    TAKEMURA, R
    ZHANG, ZZ
    NANGAKU, M
    HIROKAWA, N
    [J]. JOURNAL OF CELL BIOLOGY, 1992, 119 (05) : 1287 - 1296
  • [3] De novo mosaic MECP2 mutation in a female with Rett syndrome
    Alexandrou, Angelos
    Papaevripidou, Ioannis
    Alexandrou, Ioanna Maria
    Theodosiou, Athina
    Evangelidou, Paola
    Kousoulidou, Ludmila
    Tanteles, George
    Christophidou-Anastasiadou, Violetta
    Sismani, Carolina
    [J]. CLINICAL CASE REPORTS, 2019, 7 (02): : 366 - 370
  • [4] An M.C., 2014, PLoS Curr, V6
  • [5] Protein aggregates in Huntington's disease
    Arrasate, Montserrat
    Finkbeiner, Steven
    [J]. EXPERIMENTAL NEUROLOGY, 2012, 238 (01) : 1 - 11
  • [6] CRISPR therapeutic tools for complex genetic disorders and cancer (Review)
    Baliou, Stella
    Adamaki, Maria
    Kyriakopoulos, Anthony M.
    Spandidos, Demetrios A.
    Panayiotidis, Mihalis
    Christodoulou, Ioannis
    Zoumpourlis, Vassilis
    [J]. INTERNATIONAL JOURNAL OF ONCOLOGY, 2018, 53 (02) : 443 - 468
  • [7] Barrangou R, 2013, CRISPR CAS SYSTEMS R, P6, DOI [DOI 10.1007/978-3-642-34657-6, 10.1007/978-3-642-34657-6]
  • [8] CRISPR provides acquired resistance against viruses in prokaryotes
    Barrangou, Rodolphe
    Fremaux, Christophe
    Deveau, Helene
    Richards, Melissa
    Boyaval, Patrick
    Moineau, Sylvain
    Romero, Dennis A.
    Horvath, Philippe
    [J]. SCIENCE, 2007, 315 (5819) : 1709 - 1712
  • [9] Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation
    Basnet, Harihar
    Su, Xue B.
    Tan, Yuliang
    Meisenhelders, Jill
    Merkurjev, Dana
    Ohgi, Kenneth A.
    Hunters, Tony
    Pillus, Lorraine
    Rosenfeld, Michael G.
    [J]. NATURE, 2014, 516 (7530) : 267 - +
  • [10] Brain-derived neurotrophic factor and its clinical implications
    Bathina, Siresha
    Das, Undurti N.
    [J]. ARCHIVES OF MEDICAL SCIENCE, 2015, 11 (06) : 1164 - 1178
12345678910