Extracellular Vesicle-Mediated Communication between the Glioblastoma and Its Microenvironment

被引：76

作者：

Matarredona, Esperanza R. ^{[1
]}

Pastor, Angel M. ^{[1
]}

机构：

[1] Univ Seville, Fac Biol, Dept Fisiol, E-41012 Seville, Spain

来源：

CELLS | 2020年 / 9卷 / 01期

关键词：

tumor microenvironment; exosomes; microvesicles; glioma stem cells; TUMOR-INITIATING CELLS; GLIOMA STEM-CELLS; ENDOTHELIAL-CELLS; INTERCELLULAR COMMUNICATION; MALIGNANT GLIOMAS; BRAIN METASTASIS; MICROVESICLES; EXOSOMES; RNA; PROMOTE;

D O I：

10.3390/cells9010096

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The glioblastoma is the most malignant form of brain cancer. Glioblastoma cells use multiple ways of communication with the tumor microenvironment in order to tune it for their own benefit. Among these, extracellular vesicles have emerged as a focus of study in the last few years. Extracellular vesicles contain soluble proteins, DNA, mRNA and non-coding RNAs with which they can modulate the phenotypes of recipient cells. In this review we summarize recent findings on the extracellular vesicles-mediated bilateral communication established between glioblastoma cells and their tumor microenvironment, and the impact of this dialogue for tumor progression and recurrence.

引用

页数：13

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