One-Pot Synthesis of [1,2,3]Triazolo[1,5-a]quinoxalin-4(5H)-ones by a Metal-Free Sequential Ugi-4CR/Alkyne-Azide Cycloaddition Reaction

被引：12

作者：

Yan, Yan-Mei ^{[1
]}

Li, Hao-Yang ^{[1
]}

Zhang, Min ^{[1
]}

Wang, Rong-Xin ^{[1
]}

Zhou, Chen-Guang ^{[1
]}

Ren, Zhen-Xing ^{[2
]}

Ding, Ming-Wu ^{[3
]}

机构：

[1] Taiyuan Normal Univ, Dept Chem, Jinzhong 030619, Peoples R China

[2] Shanxi Univ, Inst Appl Chem, Taiyuan 030006, Shanxi, Peoples R China

[3] Cent China Normal Univ, Wuhan 430079, Hubei, Peoples R China

来源：

SYNLETT | 2020年 / 31卷 / 01期

基金：

中国国家自然科学基金;

关键词：

one-pot; metal-free; 1,2,3]triazolo[1,5,a]quinoxalin-4(5H)-one; Ugi reaction; alkyne-azide cycloaddition reaction; MULTICOMPONENT REACTIONS; CLICK CHEMISTRY; UGI REACTION; BENZODIAZEPINE; HETEROCYCLES; STRATEGY; INDOLES; CONCISE; BIOLOGY; BINDING;

D O I：

10.1055/s-0037-1610737

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient and one-pot approach to prepare [1,2,3]triazolo[1,5-a]quinoxalin-4(5H)-ones by a metal-free sequential Ugi-4CR/alkyne-azide cycloaddition reaction has been developed. The reaction of 2-azidobenzenamines, aldehydes, propiolic acids, and isocyanides produced the Ugi adducts, which were transformed to the [1,2,3]triazolo[1,5- a ]quinoxalin-4(5 H )-ones in moderate to good yields via alkyne-azide cycloaddition reaction.

引用

页码：73 / 76

页数：4

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