Frontiers in microbial 1-butanol and isobutanol production

被引：69

作者：

Chen, Chang-Ting ^{[1
]}

Liao, James C. ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biomol Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, UCLA DOE Inst Genom & Prote, 420 Westwood Plaza, Los Angeles, CA 90095 USA

来源：

FEMS MICROBIOLOGY LETTERS | 2016年 / 363卷 / 05期

基金：

美国国家科学基金会;

关键词：

butanol; metabolic engineering; synthetic biology; ABE fermentation; isobutanol; CLOSTRIDIUM-BEIJERINCKII BA101; BUTANOL PRODUCTION; GENOME SEQUENCE; SACCHAROMYCES-CEREVISIAE; RECOMBINANT STRAINS; ACETOBUTYLICUM; ACETONE; GENE; FERMENTATION; TOLERANCE;

D O I：

10.1093/femsle/fnw020

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The heavy dependence on petroleum-derived fuel has raised concerns about energy sustainability and climate change, which have prompted researchers to explore fuel production from renewable sources. 1-Butanol and isobutanol are promising biofuels that have favorable properties and can also serve as solvents or chemical feedstocks. Microbial production of these alcohols provides great opportunities to access a wide spectrum of renewable resources. In recent years, research has improved the native 1-butanol production and has engineered isobutanol production in various organisms to explore metabolic diversity and a broad range of substrates. This review focuses on progress in metabolic engineering for the production of these two compounds using various resources.

引用

页数：13

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