First certified reference material for cystatin C in human serum ERM-DA471/IFCC

被引：327

作者：

Grubb, Anders ^{[2
]}

Blirup-Jensen, Soren ^{[2
]}

Lindstrom, Veronica ^{[2
]}

Schmidt, Camilla ^{[2
]}

Althaus, Harald ^{[3
]}

Zegers, Ingrid ^{[1
]}

机构：

[1] Commiss European Communities, Joint Res Ctr, Inst Reference Mat & Measurements IRMM, B-2440 Geel, Belgium

[2] Univ Lund Hosp, Dept Clin Chem, S-22185 Lund, Sweden

[3] Siemens Healthcare Diagnost Prod GmbH, Marburg, Germany

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2010年 / 48卷 / 11期

关键词：

certified reference material; cystatin C; glomerular filtration rate; immunoassay; GLOMERULAR-FILTRATION-RATE; TARGET MATERIAL; PROTEIN VALUES; STANDARDIZATION; ASSIGNMENT; CREATININE;

D O I：

10.1515/CCLM.2010.318

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The IFCC Working Group for the Standardisation of Cystatin C (WG-SCC), in collaboration with the Institute for Reference Materials and Measurements (IRMM), announces the availability of the new certified reference material ERM-DA471/IFCC. The material was characterised using a pure protein primary reference preparation (PRP) as calibrant. The PRP was prepared from recombinant cystatin C, and its concentration measured using dry mass determination. The characterisation of ERM-DA471/IFCC was performed by particle enhanced immuno-nephelometry, particle enhanced immuno-turbidimetry, and enzyme amplified single radial immuno-diffusion. The certified cystatin C mass concentration in ERM-DA471/IFCC, if reconstituted according to the specified procedure, is 5.48 mg/L, the expanded uncertainty (k=2) being 0.15 mg/L. Clin Chem Lab Med 2010;48:1619-21.

引用

页码：1619 / 1621

页数：3

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