In vitro activity of tigecycline in combination with gentamicin against biofilm-forming Staphylococcus aureus

被引：23
作者：
McConeghy, Kevin W.
LaPlante, Kerry L. [1 ]
机构：
[1] Univ Rhode Isl, Dept Pharm Practice, Vet Affairs Med Ctr 151, Providence, RI 02908 USA
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2010年 / 68卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Biofilm; Combination; Gentamicin; Methicillin-resistant Staphylococcus aureus; Tigecycline; ANTIMICROBIAL ACTIVITY; DAPTOMYCIN; MODEL; VANCOMYCIN; QUANTIFICATION; THERAPY; PROFILE; IMPACT; PLATES;
D O I：
10.1016/j.diagmicrobio.2010.04.011
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We investigated the activity of tigecycline in combination with gentamicin for the treatment of biofilm-forming methicillin-resistant and sensitive Staphylococcus aureus in an in vitro pharmacodynamic model. Tigecycline monotherapy demonstrated bacteriostatic activity throughout 48 h (-0.24 +/- 0.17 log(10) CFU/mL), whereas tigecycline in combination with gentamicin demonstrated significant (P < 0.002) kill (-3.66 +/- 0.26 log(10) CFU/mL) at 48 h. The addition of gentamicin to tigecycline significantly improved the killing activity of tigecycline in biofilm-forming S. aureus. (c) 2010 Elsevier Inc. All rights reserved.
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页码：1 / 6
页数：6
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