Synthesis of 1,4-Dihydropyridines Containing Azulenes Moiety

被引：0

作者：

Wang, Daolin ^{[1
]}

Lin, Linan ^{[1
]}

Li, Shaofei ^{[1
]}

Li, Wei ^{[1
]}

Li, Yanfen ^{[1
]}

机构：

[1] Bohai Univ, Coll Chem & Chem Engn, Liaoning Key Lab Synth & Applicat Funct Compound, Jinzhou 121003, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 30卷 / 11期

关键词：

azulene; methyl; 1-formoylazulene-3-carboxylate; 1,4-dihydridine; synthesis; CALCIUM-ANTAGONISTS; DERIVATIVES;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New 1,4-dihydridine derivatives containing azulene moiety were synthesized by three component one-pot condensation of methyl 1-formoylazulene-3-carboxylate, acetoacetic esters and ammonium acetate or alkyl 3-amminocrotonate under p-toluenesulfonic acid as a catalyst This method provides several advantages such as good yield and simple work-up procedure All the products were fully characterized by H-1 NMR, IR spectra and elemental analysis

引用

页码：1774 / 1777

页数：4

共 20 条

[1]

BUHLER FR, 1987, J HYPERTENS, V5, pS3

[2] Synthesis of 4-thiophen-2′-yl-1,4-dihydropyridines as potentiators of the CFTR chloride channel [J].