Osteoarthritis - An untreatable disease?

被引:425
作者
Wieland, HA [1 ]
Michaelis, M [1 ]
Kirschbaum, BJ [1 ]
Rudolphi, KA [1 ]
机构
[1] Aventis Pharma Deutschland GmbH, Dept Therapeut, Thrombosis & Osteoarthrit, D-65926 Frankfurt, Germany
基金
美国国家卫生研究院;
关键词
D O I
10.1038/nrd1693
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Osteoarthritis is a painful and disabling disease that affects millions of patients. Its aetiology is largely unknown, but is most likely multi-factorial. Osteoarthritis poses a dilemma: it often begins attacking different joint tissues long before middle age, but cannot be diagnosed until it becomes symptomatic decades later, at which point structural alterations are already quite advanced. In this review, osteoarthritis is considered as a disease of the whole joint that may result from multiple pathophysiological mechanisms, one of which is the dysregulation of lipid homeostasis. No proven disease-modifying therapy exists for osteoarthritis and current treatment options for chronic osteoarthritic pain are insufficient, but new pharmacotherapeutic options are emerging.
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收藏
页码:331 / 344
页数:14
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