Putative dopamine neurons in the ventral tegmental area enhance information coding in the prefrontal cortex
被引:13
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Mininni, Camilo J.
[1
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Caiafa, Cesar F.
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Consejo Nacl Invest Cient & Tecn, CICPBA, CCT La Plata, IAR, Villa Elisa, ArgentinaConsejo Nacl Invest Cient & Tecn, Inst Biol & Med Expt IBYME, Buenos Aires, DF, Argentina
Caiafa, Cesar F.
[2
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Silvano Zanutto, B.
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Consejo Nacl Invest Cient & Tecn, Inst Biol & Med Expt IBYME, Buenos Aires, DF, Argentina
Univ Buenos Aires, Fac Ingn, Inst Ingn Biomed, Buenos Aires, DF, ArgentinaConsejo Nacl Invest Cient & Tecn, Inst Biol & Med Expt IBYME, Buenos Aires, DF, Argentina
Silvano Zanutto, B.
[1
,3
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Tseng, Kuei Y.
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Univ Illinois, Coll Med, Dept Anat & Cell Biol, Chicago, IL 60612 USAConsejo Nacl Invest Cient & Tecn, Inst Biol & Med Expt IBYME, Buenos Aires, DF, Argentina
Tseng, Kuei Y.
[4
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Lew, Sergio E.
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Univ Buenos Aires, Fac Ingn, Inst Ingn Biomed, Buenos Aires, DF, ArgentinaConsejo Nacl Invest Cient & Tecn, Inst Biol & Med Expt IBYME, Buenos Aires, DF, Argentina
Lew, Sergio E.
[3
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机构:
[1] Consejo Nacl Invest Cient & Tecn, Inst Biol & Med Expt IBYME, Buenos Aires, DF, Argentina
[2] Consejo Nacl Invest Cient & Tecn, CICPBA, CCT La Plata, IAR, Villa Elisa, Argentina
[3] Univ Buenos Aires, Fac Ingn, Inst Ingn Biomed, Buenos Aires, DF, Argentina
[4] Univ Illinois, Coll Med, Dept Anat & Cell Biol, Chicago, IL 60612 USA
It has been proposed that neuronal populations in the prefrontal cortex (PFC) robustly encode task-relevant information through an interplay with the ventral tegmental area (VTA). Yet, the precise computation underlying such functional interaction remains elusive. Here, we conducted simultaneous recordings of single-unit activity in PFC and VTA of rats performing a GO/NoGO task. We found that mutual information between stimuli and neural activity increases in the PFC as soon as stimuli are presented. Notably, it is the activity of putative dopamine neurons in the VTA that contributes critically to enhance information coding in the PFC. The higher the activity of these VTA neurons, the better the conditioned stimuli are encoded in the PFC.