Putative dopamine neurons in the ventral tegmental area enhance information coding in the prefrontal cortex

被引:13
作者
Mininni, Camilo J. [1 ]
Caiafa, Cesar F. [2 ]
Silvano Zanutto, B. [1 ,3 ]
Tseng, Kuei Y. [4 ]
Lew, Sergio E. [3 ]
机构
[1] Consejo Nacl Invest Cient & Tecn, Inst Biol & Med Expt IBYME, Buenos Aires, DF, Argentina
[2] Consejo Nacl Invest Cient & Tecn, CICPBA, CCT La Plata, IAR, Villa Elisa, Argentina
[3] Univ Buenos Aires, Fac Ingn, Inst Ingn Biomed, Buenos Aires, DF, Argentina
[4] Univ Illinois, Coll Med, Dept Anat & Cell Biol, Chicago, IL 60612 USA
来源
SCIENTIFIC REPORTS | 2018年 / 8卷
基金
美国国家卫生研究院;
关键词
WORKING-MEMORY; NETWORK MODEL; D1; RECEPTORS; STIMULATION; PRAMIPEXOLE; MODULATION; AGONIST; MONKEYS; STATES;
D O I
10.1038/s41598-018-29979-2
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
It has been proposed that neuronal populations in the prefrontal cortex (PFC) robustly encode task-relevant information through an interplay with the ventral tegmental area (VTA). Yet, the precise computation underlying such functional interaction remains elusive. Here, we conducted simultaneous recordings of single-unit activity in PFC and VTA of rats performing a GO/NoGO task. We found that mutual information between stimuli and neural activity increases in the PFC as soon as stimuli are presented. Notably, it is the activity of putative dopamine neurons in the VTA that contributes critically to enhance information coding in the PFC. The higher the activity of these VTA neurons, the better the conditioned stimuli are encoded in the PFC.
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页数:11
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