The Two-Way Polyphenols-Microbiota Interactions and Their Effects on Obesity and Related Metabolic Diseases

被引：199
作者：
Faraldo Correa, Telma Angelina [1 ,2 ]
Rogero, Marcelo Macedo [2 ,3 ]
Aymoto Hassimotto, Neuza Mariko [1 ,2 ]
Lajolo, Franco Maria [1 ,2 ]
机构：
[1] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Food Sci & Expt Nutr, Sao Paulo, SP, Brazil
[2] Sao Paulo Res Fdn, CEPID FAPESP Res Innovat & Disseminat Ctr, Food Res Ctr, Sao Paulo, SP, Brazil
[3] Univ Sao Paulo, Dept Nutr, Sch Publ Hlth, Sao Paulo, SP, Brazil
来源：
FRONTIERS IN NUTRITION | 2019年 / 6卷
基金：
巴西圣保罗研究基金会;
关键词：
polyphenols; obesity; inflammation; microbiome; metabolism; RED WINE POLYPHENOLS; GUT MICROBIOTA; AKKERMANSIA-MUCINIPHILA; INTESTINAL MICROBIOTA; DIETARY POLYPHENOLS; INSULIN-RESISTANCE; RESVERATROL; INFLAMMATION; MODULATION; MARKERS;
D O I：
10.3389/fnut.2019.00188
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Metabolic diseases can change the gut microbiota composition and function, and pathogenic bacteria contribute to the development of metabolic disorders. Polyphenols may act in the gut microbiota to favor the increase of beneficial bacteria and hamper the increase of pathogenic bacteria. In addition, the microbiota may act on polyphenols to increase their bioavailability. This two-way interactions between polyphenols and the gut microbiota could affect human metabolism and reduce cardiometabolic risk. Despite the possible benefits of polyphenols for human health through modulating the microbiome, studies are scarce, and present several limitations. This review provides an overview of the polyphenol-microbiota interactions and its effects on metabolic disorders.
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页数：15
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