Iodine-mediated oxidative cyclization for one pot synthesis of new 8-hydroxyquinaldine derivatives containing a N-phenylpyrazole moiety as pesticidal agents

被引：14

作者：

Xu, Ting ^{[1
]}

Wang, Xiaoguang ^{[1
]}

Zhang, Qian ^{[1
]}

Fan, Jiangping ^{[1
]}

Liu, Liu ^{[1
]}

Liu, Mingzhu ^{[1
]}

Zhang, Haojie ^{[1
]}

Li, Jing ^{[1
]}

Guo, Yong ^{[1
]}

机构：

[1] Zhengzhou Univ, Minist Educ, Key Lab Adv Drug Preparat Technol, Sch Pharmaceut Sci, Zhengzhou 450001, Henan, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2018年 / 28卷 / 20期

基金：

中国国家自然科学基金;

关键词：

8-Hydroxyquinaldine; N-Phenylpyrazole; Structural modification; Pesticidal activities; Structure-activity relationship; PYRAZOLE OXIME DERIVATIVES; BIOLOGICAL EVALUATION; INSECTICIDAL ACTIVITY; SARISAN ANALOGS; DESIGN; ANTIBACTERIAL; BIOACTIVITIES; CHEMISTRY; PROGRESS;

D O I：

10.1016/j.bmcl.2018.08.041

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In continuation of our research aimed at discovery and development of new pesticidal agents, a series of new 8hydroxyquinaldine derivatives containing a N-phenylpyrazole moiety were prepared and their structures were characterized by H-1 NMR, IR, ESI-MS and mp. Meanwhile, an efficient way of using iodine-mediated oxidative cyclization for one pot synthesis of these 8-hydroxyquinaldine derivatives containing a N-phenylpyrazole moiety was developed. The bioassay showed that compounds 8g and 9f exhibited potent pesticidal activities against both Mythimna separata Walker and Plutella xylostella Linnaeus. The structure-activity relationships were also discussed.

引用

页码：3376 / 3380

页数：5

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