Roles of Steroid Receptor Coactivator 3 in Host Defense Against Bacterial Pathogens

被引：1
|
作者：
Chen, Wenbo [1 ,2 ]
Mo, Pingli [1 ]
Yu, Chundong [1 ]
机构：
[1] Xiamen Univ, Sch Life Sci, Innovat Ctr Cell Biol, State Key Lab Cellular Stress Biol, Xiamen, Fujian, Peoples R China
[2] Xiamen Univ, Affiliated Hosp 1, Xiamen, Peoples R China
来源：
CRITICAL REVIEWS IN IMMUNOLOGY | 2018年 / 38卷 / 03期
关键词：
steroid receptor coactivator-3; host defense; bacterial infection; bacterial clearance; THYROID-HORMONE RECEPTOR; NUCLEAR-RECEPTOR; TRANSCRIPTIONAL COACTIVATOR; CITROBACTER-RODENTIUM; ESCHERICHIA-COLI; INFLAMMATORY RESPONSE; P160; COACTIVATORS; BARRIER FUNCTION; ACTIVATION; TRANSACTIVATION;
D O I：
10.1615/CritRevImmunol.2018026300
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Steroid receptor coactivator 3 (SRC-3) is a transcriptional coactivator that interacts with nuclear receptors such as the estrogen receptor and the androgen receptor and several other transcription factors to enhance their effects on target gene expression. SRC-3 plays important roles in many developmental, physiological, and pathologic events, including body growth, mammary gland development, energy homeostasis, inflammatory regulation, and cancer initiation and progression. SRC-3 has been suggested to be involved in host defense against bacterial pathogens. In this review, we summarize the roles of SRC-3 in host defense against peritoneal and enteric bacterial infection and discuss the potential clinical implications.
引用
收藏
页码：245 / 252
页数：8
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