Rapamycin Inhibits Activator Protein-1 But Not Nuclear Factor-κB Activity of Mature Bone Marrow-Derived Dendritic Cells

被引：8

作者：

Wang, G. -Y. ^{[1
]}

Chen, G. -H. ^{[1
]}

Li, H. ^{[1
]}

Huang, Y. ^{[1
]}

Zhang, J. ^{[1
]}

Jiang, N. ^{[1
]}

Chen, W. -J. ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Liver Transplantat Inst, Affiliated Hosp 3, Guangzhou 510275, Guangdong, Peoples R China

来源：

TRANSPLANTATION PROCEEDINGS | 2010年 / 42卷 / 05期

关键词：

SIGNAL-TRANSDUCTION; MATURATION; SURVIVAL; LIPOPOLYSACCHARIDE; PATHWAYS; KINASE; DEATH; LIFE;

D O I：

10.1016/j.transproceed.2010.04.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rapamycin (Rapa), a recently introduced immunosuppressive drug, appears to be effective in preventing acute allograft rejection episodes. Its effects on differentiation and maturation of dendritic cells (DCs) have been studied. In this report, we evaluated the effects of Rapa on the intracellular signal transduction pathways in mature DCs. The results showed that Rapa did not depress 1)65, p50, or I kappa B alpha expression. However, it dramatically reduced activator protein-1 activation. The fact that Rapa exerts a specific effect on activator protein-1 activity in mature DCs may contribute to its unique actions to prevent allograft rejection and induce immune tolerance.

引用

页码：1881 / 1883

页数：3

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