Ribozymes: The hammerhead swings into action

被引：9
|
作者：
Doudna, JA [1 ]
机构：
[1] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA
[2] Yale Univ, Howard Hughes Med Inst, New Haven, CT 06520 USA
来源：
CURRENT BIOLOGY | 1998年 / 8卷 / 14期
关键词：
D O I：
10.1016/S0960-9822(98)70316-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new crystal structure of a modified hammerhead ribozyme reveals an intermediate conformation that may explain discrepancies between previous structures and the required orientation of the labile bond in the ribozyme's active site.
引用
收藏
页码：R495 / R497
页数：3
相关论文
共 50 条
  • [31] Avsunviroidae family:: Viroids containing hammerhead ribozymes
    Flores, R
    Daròs, JA
    Hernández, C
    ADVANCES IN VIRUS RESEARCH, VOL 55, 2000, 55 : 271 - 323
  • [32] Hammerhead ribozymes to reduce thymidylate synthase overexpression
    Bruhn, T
    Hiddemann, W
    Kneba, M
    Bertram, J
    ANNALS OF ONCOLOGY, 1998, 9 : 153 - 153
  • [33] Hammerhead ribozymes in therapeutic target discovery and validation
    Tedeschi, Lorena
    Lande, Caterina
    Cecchettini, Antonella
    Citti, Lorenzo
    DRUG DISCOVERY TODAY, 2009, 14 (15-16) : 776 - 783
  • [34] Binary hammerhead ribozymes with high cleavage activity
    Kuznetsova, M
    Novopashina, D
    Repkova, M
    Venyaminova, A
    Vlassov, V
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2004, 23 (6-7): : 1037 - 1042
  • [35] Intronic hammerhead ribozymes are ultraconserved in the human genome
    de la Pena, Marcos
    Garcia-Robles, Inmaculada
    EMBO REPORTS, 2010, 11 (09) : 711 - 716
  • [36] Hammerhead ribozymes as therapeutic agents for bladder cancer
    Irie, A
    Kashani-Sabet, M
    Scanlon, KJ
    Uchida, T
    Baba, S
    MOLECULAR UROLOGY, 2000, 4 (02) : 61 - 66
  • [37] Enhancement of the Catalytic Activity of Hammerhead Ribozymes by Organic Cations
    Nakano, Shu-ichi
    Yamashita, Hirofumi
    Sugimoto, Naoki
    CHEMBIOCHEM, 2021, 22 (17) : 2721 - 2728
  • [38] Engineering high-speed allosteric hammerhead ribozymes
    Link, Kristian H.
    Gu, Lixia
    Ames, Tyler D.
    Yen, Laising
    Mulligan, Richard C.
    Breaker, Ronald R.
    BIOLOGICAL CHEMISTRY, 2007, 388 (08) : 779 - 786
  • [39] NEW STRUCTURAL MOTIFS FOR HAMMERHEAD RIBOZYMES - CATALYTIC ACTIVITY OF ABASIC NUCLEOTIDE SUBSTITUTED RIBOZYMES
    BEIGELMAN, L
    KARPEISKY, A
    MATULICADAMIC, J
    GONZALEZ, C
    USMAN, N
    NUCLEOSIDES & NUCLEOTIDES, 1995, 14 (3-5): : 907 - 910
  • [40] Chemically modified hammerhead ribozymes with improved catalytic rates
    Burgin, AB
    Gonzalez, C
    MatulicAdamic, J
    Karpeisky, AM
    Usman, N
    McSwiggen, JA
    Beigelman, L
    BIOCHEMISTRY, 1996, 35 (45) : 14090 - 14097
12345