At the crossroad of thiamine degradation and biosynthesis

被引：13

作者：

Bettendorff, Lucien ^{[1
]}

机构：

[1] Univ Liege, Ctr Cellular & Mol Neurobiol, B-4000 Liege, Belgium

来源：

NATURE CHEMICAL BIOLOGY | 2007年 / 3卷 / 08期

关键词：

D O I：

10.1038/nchembio0807-454

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The physiological significance of thiaminase II has escaped our understanding for many years. The recent discovery of a new thiamine salvage pathway shows that this enzyme is involved in the regeneration of precursors for thiamine biosynthesis.

引用

页码：454 / 455

页数：2

共 10 条

[1] Cofactor biosynthesis: an organic chemist's treasure trove [J].

Begley, TP .

NATURAL PRODUCT REPORTS, 2006, 23 (01) :15-25

[2] Discovery of a natural thiamine adenine nucleotide [J].

Bettendorff, Lucien ;

Wirtzfeld, Barbara ;

Makarchikov, Alexander F. ;

Mazzucchelli, Gabriel ;

Frederich, Michel ;

Gigliobianco, Tiziana ;

Gangolf, Marjorie ;

De Pauw, Edwin ;

Angenot, Luc ;

Wins, Pierre .

NATURE CHEMICAL BIOLOGY, 2007, 3 (04) :211-212

[3] Crystal structure of thiaminase-I from Bacillus thiaminolyticus at 2.0 Å resolution [J].

Campobasso, N ;

Costello, CA ;

Kinsland, C ;

Begley, TP ;

Ealick, SE .

BIOCHEMISTRY, 1998, 37 (45) :15981-15989

[4] Biochemistry - Molecular cannibalism [J].

Ealick, Steven E. ;

Begley, Tadhg P. .

NATURE, 2007, 446 (7134) :387-+

[5] A new thiamin salvage pathway [J].

Jenkins, Amy Haas ;

Schyns, Ghislain ;

Potot, Sebastien ;

Sun, Guangxing ;

Begley, Tadhg P. .

NATURE CHEMICAL BIOLOGY, 2007, 3 (08) :492-497

[6] Current mechanistic understanding of thiamin diphosphatedependent enzymatic reactions [J].

Jordan, F .

NATURAL PRODUCT REPORTS, 2003, 20 (02) :184-201

[7] Specific phosphorylation of Torpedo 43K rapsyn by endogenous kinase(s) with thiamine triphosphate as the phosphate donor [J].

Nghiêm, HO ;

Bettendorff, L ;

Changeux, JP .

FASEB JOURNAL, 2000, 14 (03) :543-554

[8] Comparative genomics of thiamin biosynthesis in procaryotes - New genes and regulatory mechanisms [J].

Rodionov, DA ;

Vitreschak, AG ;

Mironov, AA ;

Gelfand, MS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (50) :48949-48959

[9] Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II [J].

Toms, AV ;

Haas, AL ;

Park, JH ;

Begley, TP ;

Ealick, SE .

BIOCHEMISTRY, 2005, 44 (07) :2319-2329

[10] Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression [J].

Winkler, W ;

Nahvi, A ;

Breaker, RR .

NATURE, 2002, 419 (6910) :952-956

← 1 →