Body weight changes after adjuvant chemotherapy of patients with breast cancer: results of a Mexican cohort study

被引:9
作者
Vargas-Meza, A. [1 ]
Chavez-Tostado, M. [2 ]
Cortes-Flores, A. O. [1 ]
Urias-Valdez, D. [1 ]
Delgado-Gomez, M. [1 ]
Morgan-Villela, G. [1 ]
Zuloaga-Fernandez Del Valle, C. [1 ]
Jimenez-Tornero, J. [1 ]
Zuloaga-Fernandez Del Valle, R. [1 ]
Fuentes-Orozco, C. [2 ]
Garcia-Renteria, J. [2 ]
Rendon-Felix, J. [2 ]
Cuesta-Marquez, L. [2 ]
Gonzalez-Ojeda, A. [2 ]
机构
[1] ONKOS, Private Oncol Unit, Guadalajara, Jalisco, Mexico
[2] Mexican Inst Social Secur, Specialties Hosp, Western Natl Med Ctr, Res Unit Clin Epidemiol, Guadalajara, Jalisco, Mexico
关键词
adjuvant; breast cancer; chemotherapy; post-menopausal; pre-menopausal; weight gain; WOMEN; GAIN; DIAGNOSIS; ASSOCIATION; OVERWEIGHT; SURVIVAL; PATTERNS; OBESITY;
D O I
10.1111/ecc.12550
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Weight gain is observed in breast cancer patients receiving chemotherapy and is a well-known complication. Several factors that contributing to weight gain have been identified. However, there is a lack of information about factors associated with weight changes following adjuvant chemotherapy. A retrospective cohort of 200 pre- and post-menopausal Mexican patients treated for breast cancer was made. Anthropometric variables were measured before/after treatment. Biomarkers, cellular differentiation and chemotherapy were similar between groups. Weight gain occurred in 85.6% of pre-menopausal and 72.6% of post-menopausal women (p =.03). At the end of chemotherapy, weight and body mass index (BMI) did not differ significantly between pre-menopausal (69.3 +/- 12.6 kg; 26.6 +/- 4.8 kg/m(2)) and post-menopausal women (69.5 +/- 10.9 kg; 27.3 +/- 4.4 kg/m(2)) (p = .91 and 0.34). Dexamethasone doses were higher in pre-menopausal (85.7 +/- 39.1 g) than post-menopausal patients (79.2 +/- 22.5 g; p = .13). Weight loss was observed in 9.2% of pre-menopausal and 20.2% of post-menopausal patients (p = .04). A multivariate analysis revealed that age (OR = 2.7; 95% CI = 1.26-5.79; p = .01), menopausal status (OR = 2.29; 95% CI = 1.09-4.80; p =.03), dexamethasone dosage (OR = 2.1; 95% CI = 1.04-4.23; p = .03) and daily caloric intake (OR = 2.3; 95% CI = 1.12-5.10; p =.02) were independent variables that inducted weight gain. Pre-and post-menopausal women gained weight, but more pre-menopausal patients showed gain.
引用
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页数:7
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