Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic

被引：374

作者：

Blasco, Benjamin

Leroy, Didier ^{[2
]}

Fidock, David A. ^{[1
,2
]}

机构：

[1] Med Malaria Venture, Geneva, Switzerland

[2] Columbia Univ, New York, NY 10025 USA

来源：

NATURE MEDICINE | 2017年 / 23卷 / 08期

基金：

美国国家卫生研究院;

关键词：

DIHYDROARTEMISININ-PIPERAQUINE FAILURE; SULFADOXINE-PYRIMETHAMINE RESISTANCE; COPY NUMBER VARIATION; HIGH-THROUGHPUT ASSAY; CYTOCHROME-B GENE; CHLOROQUINE RESISTANCE; ATOVAQUONE-PROGUANIL; ARTEMISININ RESISTANCE; MALARIA PARASITES; IN-VITRO;

D O I：

10.1038/nm.4381

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The global adoption of artemisinin-based combination therapies (ACTs) in the early 2000s heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria. However, several Southeast Asian countries have now reported the emergence of parasites that have decreased susceptibility to artemisinin (ART) derivatives and ACT partner drugs, resulting in increasing rates of treatment failures. Here we review recent advances in understanding how antimalarials act and how resistance develops, and discuss new strategies for effectively combatting resistance, optimizing treatment and advancing the global campaign to eliminate malaria.

引用

页码：917 / 928

页数：12

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