Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal

被引：30

作者：

Fabisiak, Adam ^{[1
]}

Wlodarczyk, Jakub ^{[1
]}

Fabisiak, Natalia ^{[1
]}

Storr, Martin ^{[2
,3
]}

Fichna, Jakub ^{[1
]}

机构：

[1] Med Univ Lodz, Fac Med, Dept Biochem, Mazowiecka 6-8, PL-92215 Lodz, Poland

[2] Ctr Endoscopy, Starnberg, Germany

[3] Ludwig Maximilians Univ Munchen, Walter Brendel Ctr Expt Med, Munich, Germany

来源：

JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY | 2017年 / 23卷 / 03期

关键词：

Ebastine; Irritable bowel syndrome; Mast cells; Receptors; histamine; CELL STABILIZER KETOTIFEN; MAST-CELL; VISCERAL HYPERSENSITIVITY; COLONIC HYPERSENSITIVITY; IMMUNE REGULATION; ABDOMINAL-PAIN; H-1; RECEPTOR; RISK-FACTORS; T-CELL; IBS;

D O I：

10.5056/jnm16203

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Irritable bowel syndrome is a group of functional gastrointestinal disorders with not yet fully clarified etiology. Recent evidence suggesting that mast cells may play a central role in the pathogenesis of irritable bowel syndrome paves the way for agents targeting histamine receptors as a potential therapeutic option in clinical treatment. In this review, the role of histamine and histamine receptors is debated. Moreover, the clinical evidence of anti-histamine therapeutics in irritable bowel syndrome is discussed.

引用

页码：341 / 348

页数：8

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