Isocoumarins, miraculous natural products blessed with diverse pharmacological activities

被引：169
作者：
Saeed, Aamer [1 ]
机构：
[1] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2016年 / 116卷
关键词：
Isocoumarins; Classification; Biological activities; Natural products; BIOLOGICALLY-ACTIVE METABOLITES; BACTERIUM BACILLUS-SUBTILIS; ASYMMETRIC TOTAL-SYNTHESIS; HYDRANGEAE DULCIS FOLIUM; FUNGUS ALTERNARIA-TENUIS; STRAIN MUCOR SP; ENDOPHYTIC FUNGUS; PAEPALANTHUS-BROMELIOIDES; ANTIINFLAMMATORY ACTIVITY; VERTICILLIUM-LAMELLICOLA;
D O I：
10.1016/j.ejmech.2016.03.025
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Isocoumarins are lactonic natural products abundant in microbes and higher plants. These are considered an amazing scaffold consecrated with more or less all types of pharmacological applications. This review is complementary to the earlier reviews and aims to focus the overlooked aspects of their fascinating chemistry with special emphasis on their classification and diverse biological activities with some SAR conclusions. The most recent available literature on the structural diversity and biological activity of these natural products has been reviewed. (C) 2016 Elsevier Masson SAS. All rights reserved.
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收藏
页码：290 / 317
页数：28
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