SYNTHESIS OF CALIXARENE-METHYLENEBISPHOSPHONIC ACIDS AND THEIR INFLUENCE ON FIBRIN POLYMERIZATION

被引：1

作者：

Cherenok, S. O. ^{[2
]}

Yuschenko, O. A. ^{[2
]}

Gritsenko, P. G. ^{[1
]}

Lugovskoy, E. V. ^{[1
]}

Koshel, T. A. ^{[1
]}

Chernishov, V. I. ^{[1
]}

Koliesnik, I. O. ^{[1
]}

Kalchenko, O. I. ^{[2
]}

Komisarenko, S. V. ^{[1
]}

Kalchenko, V. I. ^{[2
]}

机构：

[1] NASU, AV Palladin Biochem Inst, UA-01601 Kiev 30, Ukraine

[2] Natl Acad Sci Ukraine, Inst Organ Chem, UA-02660 Kiev 94, Ukraine

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2011年 / 186卷 / 04期

关键词：

Calixarenes; fibrinogen; methylenebisphosphonic acids; phosphonates; thrombin;

D O I：

10.1080/10426507.2010.521212

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of hydroxycalix[4]arenes bearing one, two, or four fragments of methylenebisphosphonic acids was synthesized by the reaction of appropriate formylcalixarenes with sodium salts of dialkylphosphites. These calixarenes inhibit specifically 50% of fibrin polymerization in the fibrinogen + thrombin reaction as well as monomeric fibrin desAABB polymerization in concentration up to 0.5 x 10(-6) M.

引用

页码：964 / 965

页数：2