Can AlphaFold2 predict the impact of missense mutations on structure?

被引:177
|
作者
Buel, Gwen R. [1 ]
Walters, Kylie J. [1 ]
机构
[1] NCI, Struct Biol Ctr, Ctr Canc Res, NIH, Frederick, MD 21701 USA
基金
美国国家卫生研究院;
关键词
BRCA1;
D O I
10.1038/s41594-021-00714-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:1 / 2
页数:2
相关论文
共 50 条
  • [1] Can AlphaFold2 predict the impact of missense mutations on structure?
    Gwen R. Buel
    Kylie J. Walters
    Nature Structural & Molecular Biology, 2022, 29 : 1 - 2
  • [2] AFFIPred: AlphaFold2 structure-based Functional Impact Prediction of missense variations
    Pir, Mustafa S.
    Timucin, Emel
    PROTEIN SCIENCE, 2025, 34 (02)
  • [3] The impact of AlphaFold2 on experimental structure solution
    Edich, Maximilian
    Briggs, David C.
    Kippes, Oliver
    Gao, Yunyun
    Thorn, Andrea
    FARADAY DISCUSSIONS, 2022, 240 (00) : 184 - 195
  • [4] AlphaFold2 Can Predict Single-Mutation Effects
    McBride, John M.
    Polev, Konstantin
    Abdirasulov, Amirbek
    Reinharz, Vladimir
    Grzybowski, Bartosz A.
    Tlusty, Tsvi
    PHYSICAL REVIEW LETTERS, 2023, 131 (21)
  • [5] The impact of AlphaFold2 one year on
    Jones, David T.
    Thornton, Janet M.
    NATURE METHODS, 2022, 19 (01) : 15 - 20
  • [6] The impact of AlphaFold2 one year on
    David T. Jones
    Janet M. Thornton
    Nature Methods, 2022, 19 : 15 - 20
  • [7] AlphaFold2 fails to predict protein fold switching
    Chakravarty, Devlina
    Porter, Lauren L.
    PROTEIN SCIENCE, 2022, 31 (06)
  • [8] MoDAFold: a strategy for predicting the structure of missense mutant protein based on AlphaFold2 and molecular dynamics
    Zheng, Lingyan
    Shi, Shuiyang
    Sun, Xiuna
    Lu, Mingkun
    Liao, Yang
    Zhu, Sisi
    Zhang, Hongning
    Pan, Ziqi
    Fang, Pan
    Zeng, Zhenyu
    Li, Honglin
    Li, Zhaorong
    Xue, Weiwei
    Zhu, Feng
    BRIEFINGS IN BIOINFORMATICS, 2024, 25 (02)
  • [9] Benchmarking AlphaFold2 on peptide structure prediction
    McDonald, Eli Fritz
    Jones, Taylor
    Plate, Lars
    Meiler, Jens
    Gulsevin, Alican
    STRUCTURE, 2023, 31 (01) : 111 - +
  • [10] Predicting the pathogenicity of missense variants using features derived from AlphaFold2
    Schmidt, Axel
    Roener, Sebastian
    Mai, Karola
    Klinkhammer, Hannah
    Kircher, Martin
    Ludwig, Kerstin U.
    BIOINFORMATICS, 2023, 39 (05)