Can AlphaFold2 predict the impact of missense mutations on structure?

被引：197

作者：

Buel, Gwen R. ^{[1
]}

Walters, Kylie J. ^{[1
]}

机构：

[1] NCI, Struct Biol Ctr, Ctr Canc Res, NIH, Frederick, MD 21701 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2022年 / 29卷 / 01期

基金：

美国国家卫生研究院;

关键词：

BRCA1;

D O I：

10.1038/s41594-021-00714-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：1 / 2

页数：2

共 10 条

[1] Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension [J].

Biancospino, Matteo ;

Buel, Gwen R. ;

Nino, Carlos A. ;

Maspero, Elena ;

di Perrotolo, Rossella Scotto ;

Raimondi, Andrea ;

Redlingshofer, Lisa ;

Weber, Janine ;

Brodsky, Frances M. ;

Walters, Kylie J. ;

Polo, Simona .

NATURE COMMUNICATIONS, 2019, 10 (1)

[2] A systematic genetic assessment of 1,433 sequence variants of unknown clinical significance in the BRCA1 and BRCA2 breast cancer-predisposition genes [J].

Easton, Douglas F. ;

Deffenbaugh, Amie M. ;

Pruss, Dmitry ;

Frye, Cynthia ;

Wenstrup, Richard J. ;

Allen-Brady, Kristina ;

Tavtigian, Sean V. ;

Monteiro, Alvaro N. A. ;

Iversen, Edwin S. ;

Couch, Fergus J. ;

Goldgar, David E. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2007, 81 (05) :873-883

[3] Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains [J].

He, Fahu ;

Wollscheid, Hans-Peter ;

Nowicka, Urszula ;

Biancospino, Matteo ;

Valentini, Eleonora ;

Ehlinger, Aaron ;

Acconcia, Filippo ;

Magistrati, Elisa ;

Polo, Simona ;

Walters, Kylie J. .

CELL REPORTS, 2016, 14 (11) :2683-2694

[4] Highly accurate protein structure prediction with AlphaFold [J].

Jumper, John ;

Evans, Richard ;

Pritzel, Alexander ;

Green, Tim ;

Figurnov, Michael ;

Ronneberger, Olaf ;

Tunyasuvunakool, Kathryn ;

Bates, Russ ;

Zidek, Augustin ;

Potapenko, Anna ;

Bridgland, Alex ;

Meyer, Clemens ;

Kohl, Simon A. A. ;

Ballard, Andrew J. ;

Cowie, Andrew ;

Romera-Paredes, Bernardino ;

Nikolov, Stanislav ;

Jain, Rishub ;

Adler, Jonas ;

Back, Trevor ;

Petersen, Stig ;

Reiman, David ;

Clancy, Ellen ;

Zielinski, Michal ;

Steinegger, Martin ;

Pacholska, Michalina ;

Berghammer, Tamas ;

Bodenstein, Sebastian ;

Silver, David ;

Vinyals, Oriol ;

Senior, Andrew W. ;

Kavukcuoglu, Koray ;

Kohli, Pushmeet ;

Hassabis, Demis .

NATURE, 2021, 596 (7873) :583-+

[5] Comprehensive Analysis of Missense Variations in the BRCT Domain of BRCA1 by Structural and Functional Assays [J].

Lee, Megan S. ;

Green, Ruth ;

Marsillac, Sylvia M. ;

Coquelle, Nicolas ;

Williams, R. Scott ;

Yeung, Telford ;

Foo, Desmond ;

Hau, D. Duong ;

Hui, Ben ;

Monteiro, Alvaro N. A. ;

Glover, J. N. Mark .

CANCER RESEARCH, 2010, 70 (12) :4880-4890

[6]

Pak M. A, PREPRINT BIORXIV, DOI [10.1101/2021.09.19.460937(2021, DOI 10.1101/2021.09.19.460937(2021]

[7] Highly accurate protein structure prediction for the human proteome [J].

Tunyasuvunakool, Kathryn ;

Adler, Jonas ;

Wu, Zachary ;

Green, Tim ;

Zielinski, Michal ;

Zidek, Augustin ;

Bridgland, Alex ;

Cowie, Andrew ;

Meyer, Clemens ;

Laydon, Agata ;

Velankar, Sameer ;

Kleywegt, Gerard J. ;

Bateman, Alex ;

Evans, Richard ;

Pritzel, Alexander ;

Figurnov, Michael ;

Ronneberger, Olaf ;

Bates, Russ ;

Kohl, Simon A. A. ;

Potapenko, Anna ;

Ballard, Andrew J. ;

Romera-Paredes, Bernardino ;

Nikolov, Stanislav ;

Jain, Rishub ;

Clancy, Ellen ;

Reiman, David ;

Petersen, Stig ;

Senior, Andrew W. ;

Kavukcuoglu, Koray ;

Birney, Ewan ;

Kohli, Pushmeet ;

Jumper, John ;

Hassabis, Demis .

NATURE, 2021, 596 (7873) :590-+

[8] DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a [J].

Walters, KJ ;

Lech, PJ ;

Goh, AM ;

Wang, QH ;

Howley, PM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (22) :12694-12699

[9] Ubiquitin recognition by the DNA repair protein hHR23a [J].

Wang, QH ;

Goh, AM ;

Howley, PM ;

Walters, KJ .

BIOCHEMISTRY, 2003, 42 (46) :13529-13535

[10] Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1 [J].

Williams, RS ;

Green, R ;

Glover, JNM .

NATURE STRUCTURAL BIOLOGY, 2001, 8 (10) :838-842

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