Benzo[a]pyrene immunogenetics and immune archetype reprogramming of lung

被引：30
作者：
Abd El-Fattah, Eslam E. [1 ]
Abdelhamid, Amir Mohamed [2 ]
机构：
[1] Delta Univ Sci & Technol, Fac Pharm, Dept Biochem, Gamasa, Egypt
[2] Delta Univ Sci & Technol, Fac Pharm, Dept Pharmacol, Gamasa, Egypt
来源：
TOXICOLOGY | 2021年 / 463卷
关键词：
Benzo[a]pyrene; Immune modulation; TGF-beta; Treg; Lung cancer; TUMOR-ASSOCIATED NEUTROPHILS; LIVER NEOPLASTIC CHANGES; HEPATOCELLULAR-CARCINOMA; CELL-DIFFERENTIATION; PD-L1; EXPRESSION; GENE-EXPRESSION; IFN-GAMMA; CANCER; MACROPHAGES; BENZO(A)PYRENE;
D O I：
10.1016/j.tox.2021.152994
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Overexposure to carcinogenic precursor, benzo[a]pyrene [BaP], modulates the lung immune microenvironment. The present review seeks to elucidate novel pathways behind the tumor effect of BaP in the lungs, emphasizing immunomodulatory mediators and immune cells. In this review, BaP reprograms lung immune microenvironment through modulating transforming growth factor-beta (TGF-beta), programmed cell death 1 (PD-1), cytotoxic T lymphocyte antigen-4 (CTLA-4), Interleukin 12 (IL-12), indoleamine 2,3 dioxygenase (IDO), forkhead box protein P3 (FOXP3) and interferon-gamma (IFN-gamma) levels. Moreover, BaP modulated lung immune cellular architecture such as dendritic cells, T cells, Tregs, macrophages, neutrophils, and myeloid-derived suppressor cells (MDSCs). All mentioned changes in immune architecture and mediators lead to the induction of lung cancer.
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页数：7
相关论文
共 104 条
[41]   Inherent and Benzo[a]pyrene-Induced Differential Aryl Hydrocarbon Receptor Signaling Greatly Affects Life Span, Atherosclerosis, Cardiac Gene Expression, and Body and Heart Growth in Mice [J].
Kerley-Hamilton, Joanna S. ;
Trask, Heidi W. ;
Ridley, Christian J. A. ;
DuFour, Eric ;
Lesseur, Corina ;
Ringelberg, Carol S. ;
Moodie, Karen L. ;
Shipman, Samantha L. ;
Korc, Murray ;
Gui, Jiang ;
Shworak, Nicholas W. ;
Tomlinson, Craig R. .
TOXICOLOGICAL SCIENCES, 2012, 126 (02) :391-404
[42]   Role of tumor-associated neutrophils in regulation of tumor growth in lung cancer development: A mathematical model [J].
Kim, Yangjin ;
Lee, Donggu ;
Lee, Junho ;
Lee, Seongwon ;
Lawler, Sean .
PLOS ONE, 2019, 14 (01)
[43]  
KITAGAWA T, 1980, TOXICOL LETT, V6, P167
[44]   Effects of post-inhalation treatment with interleukin-12 on airway hyper-reactivity, eosinophilia and interleukin-18 receptor expression in a mouse model of asthma [J].
Kuribayashi, K ;
Kodama, T ;
Okamura, H ;
Sugita, M ;
Matsuyama, T .
CLINICAL AND EXPERIMENTAL ALLERGY, 2002, 32 (04) :641-649
[45]   Targeting of M2-like tumor-associated macrophages with a melittin-based pro-apoptotic peptide [J].
Lee, Chanju ;
Jeong, Hyunju ;
Bae, Younghyeon ;
Shin, Kyungmoon ;
Kang, Sinwoo ;
Kim, Hwikyung ;
Oh, Jayoung ;
Bae, Hyunsu .
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7
[46]   Preliminary mechanisms of regulating PD-L1 expression in non-small cell lung cancer during the EMT process [J].
Li, Fang ;
Zhu, Tengjiao ;
Yue, Yao ;
Zhu, Xiang ;
Wang, Jiadong ;
Liang, Li .
ONCOLOGY REPORTS, 2018, 40 (02) :775-782
[47]   CD39/CD73 upregulation on myeloid-derived suppressor cells via TGF--mTOR-HIF-1 signaling in patients with non-small cell lung cancer [J].
Li, Jieyao ;
Wang, Liping ;
Chen, Xinfeng ;
Li, Lifeng ;
Li, Yu ;
Ping, Yu ;
Huang, Lan ;
Yue, Dongli ;
Zhang, Zhen ;
Wang, Fei ;
Li, Feng ;
Yang, Li ;
Huang, Jianmin ;
Yang, Shuangning ;
Li, Hong ;
Zhao, Xuan ;
Dong, Wenjie ;
Yan, Yan ;
Zhao, Song ;
Huang, Bo ;
Zhang, Bin ;
Zhang, Yi .
ONCOIMMUNOLOGY, 2017, 6 (06)
[48]   Studies on the sources of benzo[a]pyrene in grain and aboveground tissues of rice plants [J].
Li, Peijun ;
Li, Xiaojun ;
Stagnitti, Frank ;
Zhang, Hairong ;
Lin, Xin ;
Zang, Shuyan ;
Zhuo, Junchen ;
Xiong, Xianzhe .
JOURNAL OF HAZARDOUS MATERIALS, 2009, 162 (01) :463-468
[49]   Functional Analysis of the Dioxin Response Elements (DREs) of the Murine CYP1A1 Gene Promoter: Beyond the Core DRE Sequence [J].
Li, Shuaizhang ;
Pei, Xinhui ;
Zhang, Wen ;
Xie, Heidi Qunhui ;
Zhao, Bin .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2014, 15 (04) :6475-6487
[50]   Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications [J].
Lin, Yuxin ;
Xu, Jianxin ;
Lan, Huiyin .
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2019, 12 (1)
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