PPARγ3 mRNA:: a distinct PPARγ mRNA subtype transcribed from an independent promoter

被引：292
作者：
Fajas, L [1 ]
Fruchart, JC [1 ]
Auwerx, J [1 ]
机构：
[1] Inst Pasteur, INSERM U325, Dept Atherosclerose, F-59019 Lille, France
来源：
FEBS LETTERS | 1998年 / 438卷 / 1-2期
关键词：
adipocyte differentiation; nuclear hormone receptor; insulin sensitivity;
D O I：
10.1016/S0014-5793(98)01273-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
PPAR gamma is a member of the peroxisome proliferator activated receptors (PPAR) subfamily of nuclear receptors, So far two PPAR gamma isoforms, PPAR gamma 1 and PPAR gamma 2, were known in mammals. We describe the structure of a novel human PPAR gamma subtype, PPAR gamma 3, The PPAR gamma 3 mRNA is transcribed from a novel promoter localized 5' of exon A2, PPAR gamma 3 mRNA expression was restricted to adipose tissue and large intestine. Similar to human PPAR gamma 1 and -2, PPAR gamma 3 is activated by thiazolidinediones and prostaglandin J derivatives and binds with high affinity to a PPRE. (C) 1998 Federation of European Biochemical Societies.
引用
收藏
页码：55 / 60
页数：6
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