Divergent synthesis of sialylated glycan chains: Combined use of polymer support, resin capture-release, and chemoenzymatic strategies

被引：45
作者：
Hanashima, S
Manabe, S
Ito, Y
机构：
[1] RIKEN, Inst Phys & Chem Res, Wako, Saitama 3510198, Japan
[2] CREST, JST, Kawaguchi, Saitama 3321102, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 27期
关键词：
carbohydrates; glycoproteins; glycosylation; oligosaccharides; sialic acids;
D O I：
10.1002/anie.200500777
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Carbo loading! The synthesis of α(2,3)- or α(2,6)-sialylated biantennary glycans is possible with a new approach. The common precursor 1 was synthesized with a soluble polymer support strategy (a) in combination with a resin capture-release protocol. Hexasaccharide 1 can then be diverged to various polysaccharides by enzymatic glycosylation (b). Bn = benzyl, TBS = tert-butyldimethylsilyl. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：4218 / 4224
页数：7
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