Opinion - The flexible genome

被引：142
作者：
Greenspan, RJ [1 ]
机构：
[1] Inst Neurosci, San Diego, CA 92121 USA
来源：
NATURE REVIEWS GENETICS | 2001年 / 2卷 / 05期
关键词：
D O I：
10.1038/35072018
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
A principal assumption underlying contemporary genetic analysis is that the normal function of a gene can be inferred directly from its mutant phenotype. The interactivity among genes that is now being revealed calls this assumption into question and indicates that there might be considerable flexibility in the capacity of the genome to respond to diverse conditions. The reservoir for much of this flexibility resides in the nonspecificity and malleability of gene action.
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页码：383 / 387
页数：5
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