Distinct Mechanisms of Dissemination of NDM-1 Metallo-β-Lactamase in Acinetobacter Species in Argentina

被引：23

作者：

Adams, Mark D. ^{[1
]}

Pasteran, Fernando ^{[2
]}

Traglia, German M. ^{[3
]}

Martinez, Jasmine ^{[4
]}

Huang, Fanny ^{[4
]}

Liu, Christine ^{[4
]}

Fernandez, Jennifer S. ^{[4
]}

Lopez, Carolina ^{[5
]}

Gonzalez, Lisandro J. ^{[5
,6
]}

Albornoz, Ezequiel ^{[2
]}

Corso, Alejandra ^{[2
]}

Vila, Alejandro J. ^{[5
,6
]}

Bonomo, Robert A. ^{[7
,8
,9
,10
,11
,12
,13
,14
]}

Ramirez, Maria Soledad ^{[4
]}

机构：

[1] Jackson Lab, Farmington, CT USA

[2] ANLIS Dr Carlos G Malbran, Natl Reg Reference Lab Antimicrobial Resistance N, Serv Antimicrobianos, Inst Nacl Enfermedades Infecciosas, Buenos Aires, DF, Argentina

[3] Univ Republica, Dept Desarrollo Biotecnol, Inst Higiene, Fac Med, Montevideo, Uruguay

[4] Calif State Univ Fullerton, Ctr Appl Biotechnol Studies, Dept Biol Sci, Coll Nat Sci & Math, Fullerton, CA 92634 USA

[5] UNR, Inst Biol Mol & Celular Rosario, IBR, CONICET, Rosario, Argentina

[6] Univ Nacl Rosario, Area Biofis, Fac Ciencias Bioquim & Farmaceut, Rosario, Argentina

[7] Louis Stokes Cleveland Dept Vet Affairs Med Ctr, Res Serv, Cleveland, OH USA

[8] Louis Stokes Cleveland Dept Vet Affairs Med Ctr, GRECC, Cleveland, OH USA

[9] Case Western Reserve Univ, Sch Med, Dept Med, Cleveland, OH 44106 USA

[10] Case Western Reserve Univ, Sch Med, Dept Pharmacol, Cleveland, OH 44106 USA

[11] Case Western Reserve Univ, Sch Med, Dept Mol Biol, Cleveland, OH USA

[12] Case Western Reserve Univ, Sch Med, Dept Biochem, Cleveland, OH 44106 USA

[13] Case Western Reserve Univ, Sch Med, Dept Prote & Bioinformat, Cleveland, OH USA

[14] CWRU Cleveland VAMC Ctr Antimicrobial Resistance, Cleveland, OH USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2020年 / 64卷 / 05期

关键词：

Acinetobacter baumannii; NDM-1; carbapenem resistance; Acinetobacter; carbapenems; BAUMANNII SEQUENCE TYPE-25; BLA(NDM-1); CARBAPENEMASE; COEXISTENCE; BLA(OXA-23); EMERGENCE; GENES;

D O I：

10.1128/AAC.00324-20

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A 4-year surveillance of carbapenem-resistant Acinetobacter spp. isolates in Argentina identified 40 strains carrying bla(NDM-1). Genome sequencing revealed that most were Acinetobacter baumannii, whereas seven represented other Acinetobacter spp. The A. baumannii genomes were closely related, suggesting recent spread. bla(NDM-1) was located in the chromosome of A. baumannii strains and on a plasmid in non-A. baumannii strains. A resistance gene island carrying bla(PER-7) and other resistance determinants was found on a plasmid in some A. baumannii strains.

引用

页数：6

共 24 条

[1] Quantitative assessment of insertion sequence impact on bacterial genome architecture [J].