Visible light-induced aerobic oxidative cross-coupling of glycine esters with -angelicalactone: a facile pathway to -lactams

被引：30

作者：

Zhou, Huang ^{[1
]}

Yang, Xiaorong ^{[1
]}

Li, Shilin ^{[1
]}

Zhu, Yin ^{[1
]}

Li, Ying ^{[1
]}

Zhang, Yuan ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, 222 Tianshui South Rd, Lanzhou 730000, Gansu, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 36期

基金：

中国国家自然科学基金;

关键词：

C-H INSERTION; HYDROGEN EVOLUTION REACTION; AMINO CARBONYL-COMPOUNDS; DIRECT ALPHA-ARYLATION; GAMMA-LACTAMS; PHOTOREDOX CATALYSIS; TRANSITION-METAL; C-SP3-H FUNCTIONALIZATION; STEREOSELECTIVE-SYNTHESIS; DERIVATIVES SYNTHESIS;

D O I：

10.1039/c8ob01844h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal-free aerobic oxidative dehydrogenative formal [2 + 3] cyclization of glycine esters with -angelicalactone has been accomplished via the synergistic combination of photoredox catalysis and acid catalysis. This protocol provides straightforward and facile access to a series of substituted -lactams at room temperature under an air atmosphere. Moreover, the reaction could be carried out on a gram scale. The mild conditions as well as the use of cheap substrates and catalyst make this protocol very attractive for further synthetic applications.

引用

页码：6728 / 6734

页数：7

共 32 条

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