The glossopharyngeal nerve as a novel pathway in immune-to-brain communication: relevance to neuroimmune surveillance of the oral cavity

被引：77

作者：

Romeo, HE

Tio, DL

Rahman, SU

Chiappelli, F

Taylor, AN

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Sch Med, Brain Res Inst, Los Angeles, CA 90095 USA

[3] W Los Angeles Healthcare Ctr, Vet Affairs Greater Los Angeles Healthcare Syst, Los Angeles, CA 90073 USA

[4] Univ Calif Los Angeles, Sch Dent, Div Oral Biol, Los Angeles, CA 90095 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2001年 / 115卷 / 1-2期

关键词：

glossopharyngeal nerve transection; lipopolysaccharide; interleukin-1; beta; fever; soft palate; rat;

D O I：

10.1016/S0165-5728(01)00270-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Glossopharyngeal afferents may be the neural channel by which immune challenge of the posterior oral cavity conveys information to the brain, If this is the case, then bilateral transection of the glossopharyngeal nerves (GLOx) should disrupt this communication. Injection of lipopolysaccharide (LPS) or interleukin (IL)-1 beta into the soft palate (ISP) of sham-operated rats induced a dose-related febrile response. GLOx significantly attenuated the febrile response induced by ISP injection of both LPS and IL-IP. In contrast, GLOx did not affect the febrile response when LPS or IL-1 beta were injected intraperitoneally, indicating that the effect of GLOx is not systemic. These results provide experimental evidence for a novel neural pathway for immune-to-brain communication. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：91 / 100

页数：10

共 53 条

[1] VISCEROTOPIC REPRESENTATION OF THE UPPER ALIMENTARY-TRACT IN THE RAT - SENSORY GANGLIA AND NUCLEI OF THE SOLITARY AND SPINAL TRIGEMINAL TRACTS [J].