One-pot synthesis of β-amino carbonyl compounds catalyzed silica supported phenylphosphinic acid

被引：1
作者：
Liu, Di [1 ]
Zhang, Jingwei [1 ]
Zhang, Chi [1 ]
Kou, Xiaoyan [1 ]
机构：
[1] Shandong Univ Sci & Technol, Coll Chem & Environm Engn, Qingdao 266590, Peoples R China
来源：
GREEN PROCESSING AND SYNTHESIS | 2015年 / 4卷 / 01期
基金：
中国国家自然科学基金; 中国博士后科学基金; 高等学校博士学科点专项科研基金;
关键词：
beta-amino carbonyl compounds; Mannich reaction; silica supported phenylphosphinic acid; synthesis; MANNICH REACTION; 3-COMPONENT SYNTHESIS; FACILE SYNTHESIS; IONIC LIQUIDS; KETONES; SALTS;
D O I：
10.1515/gps-2014-0077
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simple and facile synthesis of beta-amino carbonyl compounds was developed by the one-pot condensation of cyclohexanone, aromatic aldehydes and anilines at 25 degrees C in the presence of silica supported phenylphosphinic acid. beta-Amino carbonyl compounds were obtained in moderate to good yields and reasonable diastereoselectivities. This method has the advantages of short reaction time, mild reaction conditions, reusable catalyst, cost efficiency and environment friendly. In addition, acetophenone and aliphatic ketones as reactants were investigated.
引用
收藏
页码：11 / 15
页数：5
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