Intensive Care Nutrition and Post-Intensive Care Recovery

被引：11

作者：

Gunst, Jan

Van den Berghe, Greet ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Dept Cellular & Mol Med, Clin Div, Herestr 49, B-3000 Leuven, Belgium

来源：

CRITICAL CARE CLINICS | 2018年 / 34卷 / 04期

基金：

欧洲研究理事会;

关键词：

Critical illness; Feeding; Parenteral nutrition; Enteral nutrition; ICU-acquired weakness; Catabolism; Recovery; Autophagy; CRITICALLY-ILL PATIENTS; EARLY PARENTERAL-NUTRITION; ACUTE LUNG INJURY; UNIT-ACQUIRED WEAKNESS; ENTERAL NUTRITION; ENERGY PROVISION; RANDOMIZED-TRIAL; CLINICAL-TRIAL; STANDARD; OUTCOMES;

D O I：

10.1016/j.ccc.2018.06.004

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Intensive care unit (ICU)-acquired weakness frequently complicates critical illness, which prolongs intensive care dependency and causes long-term burden. Observational studies have suggested that prolonged underfeeding could aggravate ICU -acquired weakness and impair outcome. However, recent large randomized controlled trials have failed to show a benefit of early enhanced nutrition to critically ill patients. Moreover, early parenteral nutrition was even shown to increase ICU -acquired weakness and prolong organ failure and intensive care dependency, which may be explained by feeding-induced suppression of autophagy. Currently, the ideal timing of artificial nutrition for critically ill patients, as well as the optimal dose and composition, remain unclear.

引用

页码：573 / +

页数：12

共 59 条

[11]

Casaer MP, 2013, LANCET, V381, P1715, DOI 10.1016/S0140-6736(13)61068-5

[12] Role of Disease and Macronutrient Dose in the Randomized Controlled EPaNIC Trial A Post Hoc Analysis [J].

Casaer, Michael P. ;

Wilmer, Alexander ;

Hermans, Greet ;

Wouters, Pieter J. ;

Mesotten, Dieter ;

Van den Berghe, Greet .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2013, 187 (03) :247-255

[13] Early versus Late Parenteral Nutrition in Critically Ill Adults [J].

Casaer, Michael P. ;

Mesotten, Dieter ;

Hermans, Greet ;

Wouters, Pieter J. ;

Schetz, Miet ;

Meyfroidt, Geert ;

Van Cromphaut, Sophie ;

Ingels, Catherine ;

Meersseman, Philippe ;

Muller, Jan ;

Vlasselaers, Dirk ;

Debaveye, Yves ;

Desmet, Lars ;

Dubois, Jasperina ;

Van Assche, Aime ;

Vanderheyden, Simon ;

Wilmer, Alexander ;

Van den Berghe, Greet .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (06) :506-517

[14] Hypocaloric compared with eucaloric nutritional support and its effect on infection rates in a surgical intensive care unit: a randomized controlled trial [J].

Charles, Eric J. ;

Petroze, Robin T. ;

Metzger, Rosemarie ;

Hranjec, Tjasa ;

Rosenberger, Laura H. ;

Riccio, Lin M. ;

McLeod, Matthew D. ;

Guidry, Christopher A. ;

Stukenborg, George J. ;

Swenson, Brian R. ;

Willcutts, Kate F. ;

O'Donnell, Kelly B. ;

Sawyer, Robert G. .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2014, 100 (05) :1337-1343

[15] Early Parenteral Nutrition Evokes a Phenotype of Autophagy Deficiency in Liver and Skeletal Muscle of Critically Ill Rabbits [J].

Derde, Sarah ;

Vanhorebeek, Ilse ;

Guiza, Fabian ;

Derese, Inge ;

Gunst, Jan ;

Fahrenkrog, Birthe ;

Martinet, Wim ;

Vervenne, Hilke ;

Ververs, Eric-Jan ;

Larsson, Lars ;

Van den Berghe, Greet .

ENDOCRINOLOGY, 2012, 153 (05) :2267-2276

[16] Intravenous amino acid therapy for kidney function in critically ill patients: a randomized controlled trial [J].

Doig, Gordon S. ;

Simpson, Fiona ;

Bellomo, Rinaldo ;

Heighes, Philippa T. ;

Sweetman, Elizabeth A. ;

Chesher, Douglas ;

Pollock, Carol ;

Davies, Andrew ;

Botha, John ;

Harrigan, Peter ;

Reade, Michael C. .

INTENSIVE CARE MEDICINE, 2015, 41 (07) :1197-1208

[17] Early Parenteral Nutrition in Critically Ill Patients With Short-term Relative Contraindications to Early Enteral Nutrition A Randomized Controlled Trial [J].

Doig, Gordon S. ;

Simpson, Fiona ;

Sweetman, Elizabeth A. ;

Finfer, Simon R. ;

Cooper, D. Jamie ;

Heighes, Philippa T. ;

Davies, Andrew R. ;

O'Leary, Michael ;

Solano, Tom ;

Peake, Sandra .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2013, 309 (20) :2130-2138

[18] Effect of Evidence-Based Feeding Guidelines on Mortality of Critically Ill Adults A Cluster Randomized Controlled Trial [J].

Doig, Gordon S. ;

Simpson, Fiona ;

Finfer, Simon ;

Delaney, Anthony ;

Davies, Andrew R. ;

Mitchell, Imogen ;

Dobb, Geoff .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 300 (23) :2731-2741

[19] Enteral versus parenteral nutrition in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials [J].

Elke, Gunnar ;

van Zanten, Arthur R. H. ;

Lemieux, Margot ;

McCall, Michele ;

Jeejeebhoy, Khursheed N. ;

Kott, Matthias ;

Jiang, Xuran ;

Day, Andrew G. ;

Heyland, Daren K. .

CRITICAL CARE, 2016, 20

[20] Nutrition support in hospitalised adults at nutritional risk [J].

Feinberg, Joshua ;

Nielsen, Emil Eik ;

Korang, Steven Kwasi ;

Engell, Kirstine Halberg ;

Nielsen, Marie Skott ;

Zhang, Kang ;

Didriksen, Maria ;

Lund, Lisbeth ;

Lindahl, Niklas ;

Hallum, Sara ;

Liang, Ning ;

Xiong, Wenjing ;

Yang, Xuemei ;

Brunsgaard, Pernille ;

Garioud, Alexandre ;

Safi, Sanam ;

Lindschou, Jane ;

Kondrup, Jens ;

Gluud, Christian ;

Jakobsen, Janus C. .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2017, (05)

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