Intensive Care Nutrition and Post-Intensive Care Recovery

被引：11

作者：

Gunst, Jan

Van den Berghe, Greet ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Dept Cellular & Mol Med, Clin Div, Herestr 49, B-3000 Leuven, Belgium

来源：

CRITICAL CARE CLINICS | 2018年 / 34卷 / 04期

基金：

欧洲研究理事会;

关键词：

Critical illness; Feeding; Parenteral nutrition; Enteral nutrition; ICU-acquired weakness; Catabolism; Recovery; Autophagy; CRITICALLY-ILL PATIENTS; EARLY PARENTERAL-NUTRITION; ACUTE LUNG INJURY; UNIT-ACQUIRED WEAKNESS; ENTERAL NUTRITION; ENERGY PROVISION; RANDOMIZED-TRIAL; CLINICAL-TRIAL; STANDARD; OUTCOMES;

D O I：

10.1016/j.ccc.2018.06.004

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Intensive care unit (ICU)-acquired weakness frequently complicates critical illness, which prolongs intensive care dependency and causes long-term burden. Observational studies have suggested that prolonged underfeeding could aggravate ICU -acquired weakness and impair outcome. However, recent large randomized controlled trials have failed to show a benefit of early enhanced nutrition to critically ill patients. Moreover, early parenteral nutrition was even shown to increase ICU -acquired weakness and prolong organ failure and intensive care dependency, which may be explained by feeding-induced suppression of autophagy. Currently, the ideal timing of artificial nutrition for critically ill patients, as well as the optimal dose and composition, remain unclear.

引用

页码：573 / +

页数：12

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