Cell cycle regulation by the retinoblastoma family of growth inhibitory proteins

被引：169

作者：

Beijersbergen, RL ^{[1
]}

Bernards, R ^{[1
]}

机构：

[1] NETHERLANDS CANC INST, DIV MOLEC CARCINOGENESIS, 1066 CX AMSTERDAM, NETHERLANDS

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 1996年 / 1287卷 / 2-3期

关键词：

D O I：

10.1016/0304-419X(96)00002-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The retinoblastoma family of growth-inhibitory proteins act by binding and inhibiting several proteins with growth-stimulatory activity, the most prominent of which is the cellular transcription factor E2F. In higher organisms, progression through the cell division cycle is accompanied by the cyclical activation of a number of protein kinases, the cyclin-dependent kinases. Phosphorylation of retinoblastoma family proteins by these cyclin-dependent kinases leads to release of the associated growth-stimulatory proteins which in turn mediate progression through the cell division cycle.

引用

页码：103 / 120

页数：18

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