P300 component in euthymic patients with bipolar disorder type I, bipolar disorder type II and healthy controls: a preliminary event-related potential study

被引：9

作者：

Bersani, Francesco S. ^{[1
]}

Minichino, Amedeo ^{[1
]}

Fattapposta, Francesco ^{[1
]}

Mannarelli, Daniela ^{[1
]}

Pauletti, Caterina ^{[1
]}

Imperatori, Claudio ^{[2
]}

Spagnoli, Francesco ^{[1
]}

Biondi, Massimo ^{[1
]}

Delle Chiaie, Roberto ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Neurol & Psychiat, I-00185 Rome, Italy

[2] European Univ Rome, Dept Human Sci, Rome, Italy

来源：

NEUROREPORT | 2015年 / 26卷 / 04期

关键词：

bipolar disorder; event-related potential; P300; COGNITIVE IMPAIRMENT; PARIETAL CORTEX; RATING-SCALE; MANIPULATION; STIMULI; DEFICIT; TARGET; P3A;

D O I：

10.1097/WNR.0000000000000329

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of the present study was to investigate P300 event-related potential components in euthymic bipolar disorder type I (BDI) and bipolar disorder type II (BDII) patients and matched controls. A total of 10 BDI patients, 10 BDII patients and 10 healthy individuals were enrolled in the study. Event-related potential data were collected according to a standard auditory 'oddball' paradigm. A significant groups effect in both the peak amplitude (P < 0.001) and the mean amplitude (P < 0.001) was observed; post-hoc comparisons showed that the peak and mean amplitudes of BDI and BDII patients were significantly lower than the peak and mean amplitudes of the healthy controls. The neurophysiological patterns found in the present study might at least partially reflect the presence of a mild selective cognitive impairment in euthymic BDI and BDII patients. From a clinical point of view, these evidences support the potential role of cognitive interventions in the treatment of BD. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.

引用

页码：206 / 210

页数：5

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