Benzothieno[3,2-b]indole derivatives as potent selective estrogen receptor modulators

被引：29

作者：

Ji, QG

Gao, H

Wang, J

Yang, CC

Hui, X

Yan, XM

Wu, XH

Xie, YY

Wang, MW

机构：

[1] Chinese Acad Sci, Grad Sch, Shanghai Inst Mat Med, Shanghai Inst Biol Sci,State Key Lab Drug Res, Shanghai 201203, Peoples R China

[2] Natl Ctr Drug Screening, Shanghai 201203, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 11期

基金：

中国国家自然科学基金;

关键词：

SERM; benzotbieno[3,2-b]indole; estrogen receptor;

D O I：

10.1016/j.bmcl.2005.03.111

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of estrogen receptor ligands based on benzothieno[3,2-b]indole were synthesized and their binding affinity for estrogen receptor subtypes (ER alpha and ER beta) and effects on mouse uterus and bone were evaluated. Some of these compounds showed strong binding affinity to ER and significantly increased the bone mineral density of ovariectomized mice. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2891 / 2893

页数：3

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