Antibiotic-Induced Changes in the Intestinal Microbiota and Disease

被引：633

作者：

Becattini, Simone ^{[1
]}

Taur, Ying ^{[2
,3
]}

Pamer, Eric G. ^{[1
,2
,3
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Immunol Program, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Med, Infect Dis Serv, New York, NY 10065 USA

[3] Mem Sloan Kettering Canc Ctr, Lucille Castori Ctr Microbes Inflammat & Canc, New York, NY 10065 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2016年 / 22卷 / 06期

基金：

美国国家卫生研究院; 瑞士国家科学基金会;

关键词：

T-CELL RESPONSES; MEDIATED COLONIZATION RESISTANCE; SEQUENCE-SPECIFIC ANTIMICROBIALS; CLOSTRIDIUM-DIFFICILE INFECTION; HUMAN GUT MICROBIOTA; CHAIN FATTY-ACIDS; COMMENSAL BACTERIA; EPITHELIAL-CELLS; INDUCED COLITIS; IMMUNE DEFENSE;

D O I：

10.1016/j.molmed.2016.04.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The gut microbiota is a key player in many physiological and pathological processes occurring in humans. Recent investigations suggest that the efficacy of some clinical approaches depends on the action of commensal bacteria. Antibiotics are invaluable weapons to fight infectious diseases. However, by altering the composition and functions of the microbiota, they can also produce long-lasting deleterious effects for the host. The emergence of multidrug-resistant pathogens raises concerns about the common, and at times inappropriate, use of antimicrobial agents. Here we review the most recently discovered connections between host pathophysiology, microbiota, and antibiotics highlighting technological platforms, mechanistic insights, and clinical strategies to enhance resistance to diseases by preserving the beneficial functions of the microbiota.

引用

页码：458 / 478

页数：21

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