Effects of hyperthermia on infarct volume in focal embolic model of cerebral ischemia in rats

被引：43

作者：

Noor, R ^{[1
]}

Wang, CX ^{[1
]}

Shuaib, A ^{[1
]}

机构：

[1] Univ Alberta Hosp, Dept Neurol, Stroke Res Lab, Edmonton, AB 6G 2S2, Canada

来源：

NEUROSCIENCE LETTERS | 2003年 / 349卷 / 02期

关键词：

hyperthermic; middle cerebral artery; infarction; stroke;

D O I：

10.1016/S0304-3940(03)00802-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Hyperthermia worsens outcome of stoke in patients and also in animal models. In the present study, we tested the effects of hyperthermia in a focal embolic model of cerebral ischemia in rats. Focal ischemic injury was induced by embolizing a preformed clot into the middle cerebral artery. Hyperthermia significantly increased the brain infarct volume as compared to the normothermic controls measured at 48 h following the ischemic insult. Neurological deficits were also significantly elevated in the animals undergoing hyperthermic treatment. In addition, hyperthermia also significantly increased mortality. Our data thus show that hyperthermia exacerbates neuronal injury in the focal embolic model of cerebral ischemia in rats. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：130 / 132

页数：3

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