Multimodal Role of PACAP in Glioblastoma

被引:17
作者
D'Amico, Agata Grazia [1 ]
Maugeri, Grazia [2 ]
Vanella, Luca [1 ]
Pittala, Valeria [1 ]
Reglodi, Dora [3 ]
D'Agata, Velia [2 ]
机构
[1] Univ Catania, Dept Drug & Hlth Sci, I-95125 Catania, Italy
[2] Univ Catania, Sect Anat Histol & Movement Sci, Dept Biomed & Biotechnol Sci, I-95100 Catania, Italy
[3] Univ Pecs, Med Sch, Dept Anat, MTA PTE PACAP Res Grp, H-7624 Pecs, Hungary
关键词
glioblastoma multiforme; tumoral microenvironment; hypoxia; PACAP; CYCLASE-ACTIVATING POLYPEPTIDE; VASOACTIVE-INTESTINAL-PEPTIDE; GROWTH-FACTOR RECEPTOR; 4 SPLICE VARIANTS; STEM-LIKE CELLS; ADENYLATE-CYCLASE; EXTRACELLULAR DOMAIN; SIGNAL-TRANSDUCTION; SURVIVAL BENEFIT; NERVOUS-SYSTEM;
D O I
10.3390/brainsci11080994
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Glioblastoma multiforme (GBM) is the deadliest form of brain tumors. To date, the GBM therapeutical approach consists of surgery, radiation-therapy and chemotherapy combined with molecules improving cancer responsiveness to treatments. In this review, we will present a brief overview of the GBM classification and pathogenesis, as well as the therapeutic approach currently used. Then, we will focus on the modulatory role exerted by pituitary adenylate cyclase-activating peptide, known as PACAP, on GBM malignancy. Specifically, we will describe PACAP ability to interfere with GBM cell proliferation, as well as the tumoral microenvironment. Considering its anti-oncogenic role in GBM, synthesis of PACAP agonist molecules may open new perspectives for combined therapy to existing gold standard treatment.
引用
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页数:13
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