Cognitive functioning and psychiatric symptomatology in patients with chronic hepatitis C

被引:153
作者
Hilsabeck, RC
Hassanein, TI
Carlson, MD
Ziegler, EA
Perry, W
机构
[1] Texas Tech Univ, Hlth Sci Ctr, Dept Neuropsychiat & Behav Sci, Lubbock, TX 79430 USA
[2] Univ Calif San Diego, Dept Med, Div Hepatol, San Diego, CA 92103 USA
[3] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA
关键词
neuropsychological impairment; depression; fatigue; HIV;
D O I
10.1017/S1355617703960048
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Hepatitis C virus (HCV) infection is a major public-health-care problem, with over 170 million infected worldwide. Patients with chronic HCV infection often complain of various cognitive problems as well as symptoms of depression, anxiety, and fatigue. Relatively little is known, however, about the specific cognitive deficits that are common among HCV patients, and the influence of psychiatric symptomatology on cognitive functioning. In the current study of 21 chronically infected HCV patients, we assessed subjective cognitive dysfunction, depression, anxiety, and fatigue and compared these symptom areas to cognitive tests assessing visuoconstruction, learning, memory. visual attention, psychomotor speed, and mental flexibility. Results revealed that cognitive impairment ranged from 9% of patients on a visuoconstruction task to 38% of patients on a measure of complex attention, visual scanning and tracking, and psychomotor speed, and greater HCV disease severity as indicated by liver fibrosis was associated with greater cognitive dysfunction. Objective cognitive impairment was not related to subjective cognitive complaints or psychiatric symptomatology. These findings suggest that a significant portion of patients with chronic HCV experience cognitive difficulties that may interfere with activities of daily living and quality of life. Future research using cognitive measures with HCV-infected patients may assist researchers in identifying if there is a direct effect of HCV infection on the brain and which patients may be more likely to progress to cirrhosis and hepatic encephalopathy.
引用
收藏
页码:847 / 854
页数:8
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