Platform technology to identify potential disease markers and establish heritability and environmental determinants of the human serum N-glycome

被引：8
作者：
Tharmalingam, Tharmala [1 ]
Marino, Karina [1 ]
Rudd, Pauline M. [1 ]
机构：
[1] Univ Coll Dublin, Conway Inst, Dublin Oxford Glycobiol Lab, Natl Inst Bioproc Res & Training, Dublin 4, Ireland
来源：
CARBOHYDRATE RESEARCH | 2010年 / 345卷 / 10期
关键词：
Biomarker; Glycomics; High-throughput; Serum N-glycans; OVARIAN-CANCER; RHEUMATOID-ARTHRITIS; GLYCAN ANALYSIS; CELL-ADHESION; E-CADHERIN; ASSOCIATION; GLYCOSYLATION; POLYMORPHISMS; GENE; DATABASE;
D O I：
10.1016/j.carres.2010.04.012
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Glycomics has been proven to be challenging when compared to genomics, transcriptomics, or proteomics. Understanding glycans is difficult as they have a non-template driven biosynthesis and their structural characterization requires highly efficient techniques. This review will describe the robotic platform developed in our laboratory for high-throughput analysis of N-glycans, and some of the advances obtained in the Glyco-biomarker field obtained in the last three years, including the first Genome-Wide Association Study showing a direct link between DNA polymorphisms and glycosylation. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1280 / 1282
页数：3
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