Search for Osteoarthritis Genetic Markers in Women with Undifferentiated Connective Tissue Dysplasia

被引：1
作者：
Khusainova, R. I. [1 ]
Tyurin, A. V. [2 ]
Shapovalova, D. A. [1 ]
Khusnutdinova, E. K. [1 ]
机构：
[1] Russian Acad Sci, Inst Biochem & Genet, Ufa Sci Ctr, Ufa 450054, Russia
[2] Bashkir State Med Univ, Dept Hosp Therapy 2, Ufa 450076, Russia
来源：
RUSSIAN JOURNAL OF GENETICS | 2017年 / 53卷 / 07期
关键词：
osteoarthritis; arthrosis; genetic predisposition; connective tissue dysplasia; candidate genes; GENOME-WIDE ASSOCIATION; HAND OSTEOARTHRITIS; KNEE OSTEOARTHRITIS; POLYMORPHISMS; RISK; SUSCEPTIBILITY; COL2A1; LOCUS; PROGRESSION; LINKAGE;
D O I：
10.1134/S1022795417060072
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We conducted an association study of ten polymorphisms in six candidate genes of OA (rs1799750 (MMP1), rs35068180 (MMP3), rs2252070 (MMP13), rs63118460 and rs2276455 (COL2A1), rs143383 (GDF5), rs1544410, rs7975232, rs731236, and rs2228570 (VDR)) with the development of osteoarthritis (OA) in 333 women taking into account the localization of the pathological process, the age of disease manifestation, and ethnicity and investigated the presence of signs of undifferentiated connective tissue dysplasia (UCTD). On the basis of clinical and genetic data, we revealed statistically significant models to predict the development of osteoarthritis of various localizations (knee, hip, and generalized forms).
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页码：785 / 794
页数：10
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