The Pioneer Round of Translation: Features and Functions

被引：166
作者：
Maquat, Lynne E. [1 ,2 ]
Tarn, Woan-Yuh [1 ,2 ,4 ]
Isken, Olaf [3 ]
机构：
[1] Univ Rochester, Sch Med & Dent, Dept Biochem & Biophys, Rochester, NY 14642 USA
[2] Univ Rochester, Sch Med & Dent, Ctr RNA Biol, Rochester, NY 14642 USA
[3] Univ Lubeck, Inst Virol & Cell Biol, D-23562 Lubeck, Germany
[4] Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan
来源：
CELL | 2010年 / 142卷 / 03期
关键词：
MESSENGER-RNA DECAY; EXON-JUNCTION COMPLEX; UPF1; PHOSPHORYLATION; ENHANCE TRANSLATION; PROLONGED HYPOXIA; GENE-EXPRESSION; BINDING-PROTEIN; NONSENSE; MECHANISMS; INITIATION;
D O I：
10.1016/j.cell.2010.07.022
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In mammalian cells, newly synthesized mRNAs undergo a pioneer round of translation that is important for mRNA quality control. Following maturation of messenger ribonucleoprotein particles during and after the pioneer round, steady-state cycles of mRNA translation generate most of the cell's proteins. Translation factors, RNA-binding proteins, and targets of signaling pathways that are particular to newly synthesized mRNAs regulate critical functions of the pioneer round.
引用
收藏
页码：368 / 374
页数：7
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共 38 条
  • [1] Translational control of localized mRNAs: restricting protein synthesis in space and time
    Besse, Florence
    Ephrussi, Anne
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2008, 9 (12) : 971 - 980
  • [2] Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with PYM to enhance translation of viral intronless mRNAs
    Boyne, James R.
    Jackson, Brian R.
    Taylor, Adam
    Macnab, Stuart A.
    Whitehouse, Adrian
    [J]. EMBO JOURNAL, 2010, 29 (11) : 1851 - 1864
  • [3] SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein
    Cakmakci, Nihal G.
    Lerner, Rachel S.
    Wagner, Eric J.
    Zheng, Lianxing
    Marzluff, William F.
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (03) : 1182 - 1194
  • [4] microRNA/Argonaute 2 regulates nonsense-mediated messenger RNA decay
    Choe, Junho
    Cho, Hana
    Lee, Hyung Chul
    Kim, Yoon Ki
    [J]. EMBO REPORTS, 2010, 11 (05) : 380 - 386
  • [5] The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1
    Chou, MM
    Blenis, J
    [J]. CELL, 1996, 85 (04) : 573 - 583
  • [6] Dendritic LSm1/CBP80-mRNPs mark the early steps of transport commitment and translational control
    di Penta, Alessandra
    Mercaldo, Valentina
    Florenzano, Fulvio
    Munck, Sebastian
    Ciotti, M. Teresa
    Zalfa, Francesca
    Mercanti, Delio
    Molinari, Marco
    Bagni, Claudia
    Achsel, Tilmann
    [J]. JOURNAL OF CELL BIOLOGY, 2009, 184 (03) : 423 - 435
  • [7] The molecular basis for the regulation of the cap-binding complex by the importins
    Dias, Sandra M. G.
    Wilson, Kristin F.
    Rojas, Katherine S.
    Ambrosio, Andre L. B.
    Cerione, Richard A.
    [J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2009, 16 (09) : 930 - U51
  • [8] PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs
    Diem, Michael D.
    Chan, Chia C.
    Younis, Ihab
    Dreyfuss, Gideon
    [J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2007, 14 (12) : 1173 - 1179
  • [9] Disassembly of Exon Junction Complexes by PYM
    Gehring, Niels H.
    Lamprinaki, Styliani
    Kulozik, Andreas E.
    Hentze, Matthias W.
    [J]. CELL, 2009, 137 (03) : 536 - 548
  • [10] The EJC factor eIF4AIII modulates synaptic strength and neuronal protein expression
    Giorgi, Corinna
    Yeo, Gene W.
    Stone, Martha E.
    Katz, Donald B.
    Burge, Christopher
    Turrigiano, Gina
    Moore, Melissa J.
    [J]. CELL, 2007, 130 (01) : 179 - 191
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