The Pioneer Round of Translation: Features and Functions

被引：171

作者：

Maquat, Lynne E. ^{[1
,2
]}

Tarn, Woan-Yuh ^{[1
,2
,4
]}

Isken, Olaf ^{[3
]}

机构：

[1] Univ Rochester, Sch Med & Dent, Dept Biochem & Biophys, Rochester, NY 14642 USA

[2] Univ Rochester, Sch Med & Dent, Ctr RNA Biol, Rochester, NY 14642 USA

[3] Univ Lubeck, Inst Virol & Cell Biol, D-23562 Lubeck, Germany

[4] Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan

来源：

CELL | 2010年 / 142卷 / 03期

关键词：

MESSENGER-RNA DECAY; EXON-JUNCTION COMPLEX; UPF1; PHOSPHORYLATION; ENHANCE TRANSLATION; PROLONGED HYPOXIA; GENE-EXPRESSION; BINDING-PROTEIN; NONSENSE; MECHANISMS; INITIATION;

D O I：

10.1016/j.cell.2010.07.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In mammalian cells, newly synthesized mRNAs undergo a pioneer round of translation that is important for mRNA quality control. Following maturation of messenger ribonucleoprotein particles during and after the pioneer round, steady-state cycles of mRNA translation generate most of the cell's proteins. Translation factors, RNA-binding proteins, and targets of signaling pathways that are particular to newly synthesized mRNAs regulate critical functions of the pioneer round.

引用

页码：368 / 374

页数：7

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