Ferrit(in)ing Out New Mechanisms in Iron Homeostasis

被引：16

作者：

Andrews, Nancy C. ^{[1
,2
]}

机构：

[1] Duke Univ, Dept Pediat & Pharmacol, Durham, NC 27710 USA

[2] Duke Univ, Dept Canc Biol, Durham, NC 27710 USA

来源：

CELL METABOLISM | 2010年 / 12卷 / 03期

关键词：

MUTATION; DISEASE; MICE;

D O I：

10.1016/j.cmet.2010.08.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Exquisite control of intestinal iron absorption prevents iron deficiency and toxic iron overload. Absorption is modulated by a circulating hormone, hepcidin, which inactivates the iron transporter ferroportin. In this issue of Cell Metabolism, Vanoaica and colleagues show that absorption is also regulated within the intestinal epithelium, through production of the iron-sequestering protein H-ferritin.

引用

页码：203 / 204

页数：2

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