The influence of lipoic acid on adriamycin-induced hyperlipidemic nephrotoxicity in rats

被引：23
作者：
Malarkodi, KP [1 ]
Balachandar, AV [1 ]
Varalakshmi, P [1 ]
机构：
[1] Univ Madras, Dept Med Biochem, Dr ALM Post Grad Inst Basic Med Sci, Madras 600113, Tamil Nadu, India
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2003年 / 247卷 / 1-2期
关键词：
lipoic acid; antioxidant; adriamycin; nephropathy; hyperlipidemia;
D O I：
10.1023/A:1024175325850
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Adriamycin widely used in the treatment of neoplastic conditions is nephrotoxic. In the present study the protective effect of lipoic acid was investigated in adriamycin-induced nephrotoxicity in adult male albino Wistar rats. Adriamycin-induced nephrotoxicity was characterized by hyperlipidemia, proteinuria, and hypoproteinemia, by decreased activities of the enzymes N-acetyl-beta-D-glucosaminidase and cathepsin D, by increased lipid peroxidation and decreases in serum catalase and glutathione activities, and by increased urinary and serum urea, creatinine and urinary glycosaminoglycans. Pretreatment with lipoic acid restored the changes, indicating that lipoic acid is renoprotective in adriamycin nephrotoxicity.
引用
收藏
页码：139 / 145
页数：7
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