Hippocampal BDNF Expression in a Tau Transgenic Mouse Model

被引：12

作者：

Burnouf, Sylvie ^{[1
,2
,3
]}

Belarbi, Karim ^{[1
,2
,3
]}

Troquier, Laetitia ^{[1
,2
]}

Derisbourg, Maxime ^{[1
,2
]}

Demeyer, Dominique ^{[1
,2
]}

Leboucher, Antoine ^{[1
,2
]}

Laurent, Cyril ^{[1
,2
]}

Hamdane, Malika ^{[1
,2
]}

Buee, Luc ^{[1
,2
,3
]}

Blum, David ^{[1
,2
,3
]}

机构：

[1] Univ Lille Nord France, UDSL, F-59000 Lille, France

[2] Jean Pierre Aubert Res Ctr, INSERM, U837, F-59000 Lille, France

[3] CHRU Lille, F-59000 Lille, France

来源：

CURRENT ALZHEIMER RESEARCH | 2012年 / 9卷 / 04期

关键词：

Alzheimer's disease; BDNF; neurotrophins; tau; tauopathies; transgenic models; NERVE GROWTH-FACTOR; NEUROTROPHIC FACTOR; ALZHEIMERS-DISEASE; MEMORY DEFICITS; SPATIAL MEMORY; MESSENGER-RNA; VOLUNTARY EXERCISE; ADULT RATS; BRAIN; MICE;

D O I：

10.2174/156720512800492468

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by extracellular accumulation of amyloid deposits and intracellular neurofibrillary tangles (NFT) composed of hyperphosphorylated Tau proteins. Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor playing a critical role in hippocampal synaptic plasticity and memory and whose levels have been shown reduced in AD brains. While recent data support a pivotal role of beta-amyloid peptides towards BDNF decrease, whether Tau pathology impacts on BDNF expression remains unknown so far. In the present study, we have evaluated this relationship using quantitative PCR, Western blot and ELISA in the THY-Tau22 transgenic strain, known to display a progressive development of both hippocampal AD-like Tau pathology and memory impairments. We observed that Tau pathology was not associated with down-regulation of BDNF at the protein and mRNA levels in this model, suggesting that the alteration of BDNF homeostasis observed in AD patients' brains might rather be ascribed to amyloid pathology.

引用

页码：406 / 410

页数：5

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[31] Long-term environmental enrichment leads to regional increases in neurotrophin levels in rat brain [J].