The Expression and Distribution of Xenogeneic Targeted Antigens on Porcine Bone Tissue

被引：18
作者：
Feng, W. [1 ]
Fu, L. [1 ]
Liu, J. [1 ]
Li, D. [1 ]
机构：
[1] Jilin Univ, Bone & Joint Dept, Hosp 1, Changchun 130023, Jilin, Peoples R China
来源：
TRANSPLANTATION PROCEEDINGS | 2012年 / 44卷 / 05期
关键词：
ALPHA-GAL EPITOPE; XENOTRANSPLANTATION; CELLS;
D O I：
10.1016/j.transproceed.2011.11.070
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Objective. The objective of this study was to investigate the distribution of alpha-galactosyl (alpha-Gal), major histocompatibility complex (MHC)-I, and MHC-II antigens on adult porcine bone tissue. Methods. Distribution of alpha-Gal, MHC-I, and MHC-II antigens on porcine bone tissue were observed using immunohistochemistry. Results. alpha-Gal, MHC-I xenogeneic antigens were extensively observed on the surface of bone marrow cells, osteocytes, osteoblasts, and Harversian canals; MHC-II antigens were mainly expressed on bone marrow cells. Conclusion. alpha-Gal, MHC-I, and MHC-II are the main xenogeneic antigens that must be deleted to avoid xenogeneic immune reactions against bone xenografts.
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收藏
页码：1419 / 1422
页数：4
相关论文
共 13 条
[1]   Xenotransplantation - current status and future perspectives [J].
Cozzi, Emanuele ;
Bosio, Erika ;
Seveso, Michela ;
Vadori, Marta ;
Ancona, Ermanno .
BRITISH MEDICAL BULLETIN, 2005, 75-76 :99-114
[2]   Carbohydrates in xenotransplantation [J].
Ezzelarab, M ;
Ayares, D ;
Cooper, DKC .
IMMUNOLOGY AND CELL BIOLOGY, 2005, 83 (04) :396-404
[3]   A sensitive assay for measuring α-gal epitope expression on cells by a monoclonal anti-Gal antibody [J].
Galili, U ;
LaTemple, DC ;
Radic, MZ .
TRANSPLANTATION, 1998, 65 (08) :1129-1132
[4]   Xenotransplantation:: the importance of the Ga1α1,3Gal epitope in hyperacute vascular rejection [J].
Joziasse, DH ;
Oriol, R .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1999, 1455 (2-3) :403-418
[5]   The biology of bone grafting [J].
Khan, SN ;
Cammisa, FP ;
Sandha, HS ;
Diwan, AD ;
Girardi, FP ;
Lane, JM .
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS, 2005, 13 (01) :77-86
[6]   Xenotransplantation in orthopaedic surgery [J].
Laurencin, Cato T. ;
El-Amin, Saadiq F. .
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS, 2008, 16 (01) :4-8
[7]   The Galα1,3Galβ1,4GlcNAc-R (α-Gal) epitope:: A carbohydrate of unique evolution and clinical relevance [J].
Macher, Bruce A. ;
Galili, Uri .
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2008, 1780 (02) :75-88
[8]  
Platt JL, 1998, NATURE, V392, P11
[9]   Progress towards clinical xenotransplantation [J].
Schuurman, Henk-Jan ;
Pierson, Richard N., III .
FRONTIERS IN BIOSCIENCE-LANDMARK, 2008, 13 :204-220
[10]   Immunological responses to bone soluble proteins in recipients of bone allografts [J].
VandeVord, PJ ;
Nasser, S ;
Wooley, PH .
JOURNAL OF ORTHOPAEDIC RESEARCH, 2005, 23 (05) :1059-1064
12